Effect of probucol in a murine model of slowly progressive polycystic kidney disease

Shizuko Nagao, Tamio Yamaguchi, Masao Kasahara, Masatomo Kusaka, Jun Matsuda, Noboru Ogiso, Hisahide Takahashi, Jared J. Grantham

研究成果: ジャーナルへの寄稿学術論文査読

21 被引用数 (Scopus)


Epithelial proliferation, extracellular matrix remodeling, and interstitial inflammation are central elements in the pathogenesis of slowly progressive polycystic kidney disorders. Probucol, an antioxidant that lowers plasma cholesterol, has been shown to decrease smooth muscle cell proliferation and macrophage accumulation in blood vessels and to prevent restenosis after coronary angioplasty. We determined in 30-day-old male BDF1- pcy hybrid mice (derived from mating DBA/2FG-pcy and C57BL/6FG-pcy) the effect of probucol administered in the diet (1%) for 200 days on kidney weight relative to body weight (KW/BW), cyst expansion, renal interstitial fibrosis, and serum urea nitrogen (SUN) concentration. Animals were fed a moderately high-protein diet (HPD, 36%) to accentuate the development of renal cysts and to promote interstitial fibrosis. Probucol decreased serum cholesterol from 68 to 16 mg/dL but had no effect on food intake or body weight. Probucol decreased relative kidney size from 4.16% ± 0.55% to 2.64% ± 0.12% KW/BW (P < 0.01), SUN from 30.5 ± 1.8 to 25.9 ± 1.0 mg/dL (P < 0.05), cystic index from 2.45 ± 0.11 to 1.36 ± 0.10 (P < 0.01), and fibrosis index from 2.40 ± 0.11 to 1.82 ± 0.08 (P < 0.01). We conclude that probucol ameliorates the progressive deterioration in renal function and structure in pcy mice ingesting a relatively high level of dietary protein. (C) 2000 National Kidney Foundation, Inc.

ジャーナルAmerican Journal of Kidney Diseases
出版ステータス出版済み - 2000

All Science Journal Classification (ASJC) codes

  • 腎臓病学


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