Effect of Pulsatile Left Ventricular Assist System Implantation on Doppler Measurements of Renal Hemodynamics in Patients With Advanced Heart Failure

Yoshio Iwashima, Masanobu Yanase, Takeshi Horio, Osamu Seguchi, Yoshihiro Murata, Tomoyuki Fujita, Kouichi Toda, Yuhei Kawano, Takeshi Nakatani

研究成果: ジャーナルへの寄稿学術論文査読

19 被引用数 (Scopus)

抄録

The effects of left ventricular assist system (LVAS) implantation on renal hemodynamics remains to be fully elucidated. We evaluated renal function and intrarenal blood flow in five advanced heart failure patients who had been supported with a Toyobo LVAS for bridge to heart transplantation. Renal function expressed as estimated glomerular filtration rate (eGFR) was calculated using the modified formula of Modification of Diet in Renal Disease. Mean blood velocities in the bilateral segmental arteries during systolic and diastolic perfusion were measured using duplex Doppler sonography, and renal vascular resistance (resistive index [RI]) of the segmental arteries was defined as (peak systolic velocity [PSV]-end-diastolic velocity [EDV])/PSV. All studies were performed before and after implantation (mean duration of support, 15.6±10.9 months). LVAS implantation significantly improved eGFR (42.7±7.9 to 64.1±16.3mL/min, P< 0.05). Beat-by-beat measurements of heart rate did not change significantly. Mean PSV decreased significantly (38.2±8.9 to 28.3±2.2cm/s, P<0.05), and mean EDV increased significantly (8.3±3.2 to 11.3±1.3cm/s, P< 0.05), and thus, mean RI was significantly improved (0.79±0.06 to 0.60±0.04, P<0.01). In conclusion, in advanced heart failure patients, pulsatile LVAS implantation is associated with improved renal function, and this improvement may be mediated in part through an improvement of intrarenal hemodynamics.

本文言語英語
ページ(範囲)353-358
ページ数6
ジャーナルArtificial Organs
36
4
DOI
出版ステータス出版済み - 04-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 医学(その他)
  • 生体材料
  • 生体医工学

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