Effect of pyridone carboxylic acid anti-microbials on the generation of reactive oxygen species in vitro

H. Akamatsu, Y. Niwa, H. Sasaki, Y. Matoba, Y. Asada, T. Horio

研究成果: Article査読

14 被引用数 (Scopus)

抄録

The effects of ofloxacin, ciprofloxacin and balofloxacin on the reactive oxygen species (ROS) levels generated by human neutrophils was examined in vitro; ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed. The species investigated were superoxide radical anion (O2-), hydrogen peroxide (H,O,) and hydroxyl radical (OH·). Both ofloxacin and ciprofloxacin markedly decreased the levels of O2-, H2O2 and OH· generated by human neutrophils. On the other hand, these drugs did not affect any of the ROS examined in the xanthine-xanthine oxidase system. Balofloxacin showed no significant effect on ROS generated by either system. The present study indicates that ofloxacin and ciprofloxacin may exert an anti-inflammatory action by reducing the potent ROS species excessively generated by neutrophils at the sites of inflammation.

本文言語English
ページ(範囲)345-351
ページ数7
ジャーナルJournal of International Medical Research
24
4
DOI
出版ステータスPublished - 01-01-1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 細胞生物学
  • 生化学、医学

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