Effect of radical trachelectomy on ovarian reserve: A single-institute prospective study

Atsushi Nakagawa, Satoshi Tamauchi, Mamiko Sato, Masato Yoshihara, Akira Yokoi, Yusuke Shimizu, Yoshiki Ikeda, Nobuhisa Yoshikawa, Kaoru Niimi, Satoko Osuka, Hiroaki Kajiyama

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Aim: Reduced responses to controlled ovarian stimulation (COS) after radical trachelectomy (RT) have been previously reported. We aimed to assess the effect of RT on ovarian reserve by measuring anti-Müllerian hormone (AMH) levels before and after the procedure in this prospective study. Methods: We included 12 patients who underwent RT between September 2019 and December 2021 in this study. Serum AMH levels were measured preoperatively, 1 month postoperatively, and 6 months postoperatively. Differences in the AMH levels were assessed using a paired t-test. Results: The median age of the patients was 30.6 years, and the median follow-up time was 30.1 months. AMH levels at 1 and 6 months postoperatively did not show a consistent trend. At 1 month postoperatively, the average AMH level decreased insignificantly but returned to preoperative levels at 6 months. The differences in AMH levels before and after RT were insignificant. Conclusion: Our findings indicate that RT did not affect ovarian reserve as measured by AMH levels. However, the relationship between unchanged ovarian reserve and reduced response to COS remains unclear. Further research with larger sample sizes and additional measures of ovarian function is needed to corroborate these results and investigate the long-term effects of RT on ovarian reserve. Understanding these mechanisms will help guide surgical practices and provide patients with valuable information about their reproductive outcomes after RT.

本文言語英語
ページ(範囲)212-217
ページ数6
ジャーナルJournal of Obstetrics and Gynaecology Research
50
2
DOI
出版ステータス出版済み - 02-2024
外部発表はい

All Science Journal Classification (ASJC) codes

  • 産婦人科学

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