Effect of RANTES promoter genotype on the severity of intestinal metaplasia in helicobacter pylori-infected Japanese subjects

Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Hiromi Yamashita, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Hiroshi Fujita, Mitsuo Nagasaka, Masami Iwata, Kazuya Takahama, Makoto Watanabe, Hiroshi Nakano, Ichiro Hirata

研究成果: Article

7 引用 (Scopus)

抄録

Background A complex interaction of host genetic and environmental factors may be relevant in the development of Helicobacter pylori (H. pylori)-related gastro-duodenal diseases. RANTES is a potent chemoattractant peptide for memory T lymphocytes and eosinophils, and has been shown to be enhanced in H. pylori-infected gastric mucosa. We aimed to clarify the effect of RANTES functional promoter polymorphism on the risk of gastro-duodenal diseases in a Japanese population. Methods Four hundred and eighty-three subjects, comprising 106 gastric ulcer, 52 duodenal ulcer, and 325 non-ulcer subjects, were included in this study. Restriction fragment length polymorphism (RFLP) analysis was performed for polymorphisms at -28 C/G in the RANTES gene promoter region. Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system. Results There were no significant differences in the RANTES promoter genotype distributions among non-ulcer subjects, ulcer patients, and gastric and duodenal ulcers. However, the degree of intestinal metaplasia was significantly lower among G carriers in H. pylori-infected subjects aged 60 years or older (C/C vs. G carriers; 1.28 ± 1.02 vs. 0.83 ± 0.89, P = 0.0357). In addition, we also found that the same genotype held a lower risk of more severe intestinal metaplasia in H. pylori-infected female subjects (C/C vs. G carriers; 0.91 ± 1.03 vs. 0.41 ± 0.73, P = 0.0443). Conclusion The polymorphism of RANTES promoter is not associated with the susceptibility to peptic ulcer diseases, but the -28 G carrier is associated with a reduced risk of developing more severe intestinal metaplasia in H. pylori-positive subjects aged 60 years and older and in female subjects.

元の言語English
ページ(範囲)1247-1252
ページ数6
ジャーナルDigestive Diseases and Sciences
54
発行部数6
DOI
出版物ステータスPublished - 01-06-2009

Fingerprint

Chemokine CCL5
Metaplasia
Helicobacter pylori
Genotype
Duodenal Diseases
Stomach Ulcer
Duodenal Ulcer
Gastric Mucosa
Peptide T
Chemotactic Factors
Gastritis
Peptic Ulcer
Eosinophils
Genetic Promoter Regions
Restriction Fragment Length Polymorphisms
Ulcer
T-Lymphocytes
Population
Genes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

これを引用

Tahara, Tomomitsu ; Arisawa, Tomiyasu ; Shibata, Tomoyuki ; Nakamura, Masakatsu ; Yamashita, Hiromi ; Yoshioka, Daisuke ; Okubo, Masaaki ; Maruyama, Naoko ; Kamano, Toshiaki ; Kamiya, Yoshio ; Fujita, Hiroshi ; Nagasaka, Mitsuo ; Iwata, Masami ; Takahama, Kazuya ; Watanabe, Makoto ; Nakano, Hiroshi ; Hirata, Ichiro. / Effect of RANTES promoter genotype on the severity of intestinal metaplasia in helicobacter pylori-infected Japanese subjects. :: Digestive Diseases and Sciences. 2009 ; 巻 54, 番号 6. pp. 1247-1252.
@article{2fcdb5cfa33c4fd69900126987223bc1,
title = "Effect of RANTES promoter genotype on the severity of intestinal metaplasia in helicobacter pylori-infected Japanese subjects",
abstract = "Background A complex interaction of host genetic and environmental factors may be relevant in the development of Helicobacter pylori (H. pylori)-related gastro-duodenal diseases. RANTES is a potent chemoattractant peptide for memory T lymphocytes and eosinophils, and has been shown to be enhanced in H. pylori-infected gastric mucosa. We aimed to clarify the effect of RANTES functional promoter polymorphism on the risk of gastro-duodenal diseases in a Japanese population. Methods Four hundred and eighty-three subjects, comprising 106 gastric ulcer, 52 duodenal ulcer, and 325 non-ulcer subjects, were included in this study. Restriction fragment length polymorphism (RFLP) analysis was performed for polymorphisms at -28 C/G in the RANTES gene promoter region. Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system. Results There were no significant differences in the RANTES promoter genotype distributions among non-ulcer subjects, ulcer patients, and gastric and duodenal ulcers. However, the degree of intestinal metaplasia was significantly lower among G carriers in H. pylori-infected subjects aged 60 years or older (C/C vs. G carriers; 1.28 ± 1.02 vs. 0.83 ± 0.89, P = 0.0357). In addition, we also found that the same genotype held a lower risk of more severe intestinal metaplasia in H. pylori-infected female subjects (C/C vs. G carriers; 0.91 ± 1.03 vs. 0.41 ± 0.73, P = 0.0443). Conclusion The polymorphism of RANTES promoter is not associated with the susceptibility to peptic ulcer diseases, but the -28 G carrier is associated with a reduced risk of developing more severe intestinal metaplasia in H. pylori-positive subjects aged 60 years and older and in female subjects.",
author = "Tomomitsu Tahara and Tomiyasu Arisawa and Tomoyuki Shibata and Masakatsu Nakamura and Hiromi Yamashita and Daisuke Yoshioka and Masaaki Okubo and Naoko Maruyama and Toshiaki Kamano and Yoshio Kamiya and Hiroshi Fujita and Mitsuo Nagasaka and Masami Iwata and Kazuya Takahama and Makoto Watanabe and Hiroshi Nakano and Ichiro Hirata",
year = "2009",
month = "6",
day = "1",
doi = "10.1007/s10620-008-0497-2",
language = "English",
volume = "54",
pages = "1247--1252",
journal = "American Journal of Digestive Diseases",
issn = "0002-9211",
publisher = "Springer New York",
number = "6",

}

Tahara, T, Arisawa, T, Shibata, T, Nakamura, M, Yamashita, H, Yoshioka, D, Okubo, M, Maruyama, N, Kamano, T, Kamiya, Y, Fujita, H, Nagasaka, M, Iwata, M, Takahama, K, Watanabe, M, Nakano, H & Hirata, I 2009, 'Effect of RANTES promoter genotype on the severity of intestinal metaplasia in helicobacter pylori-infected Japanese subjects', Digestive Diseases and Sciences, 巻. 54, 番号 6, pp. 1247-1252. https://doi.org/10.1007/s10620-008-0497-2

Effect of RANTES promoter genotype on the severity of intestinal metaplasia in helicobacter pylori-infected Japanese subjects. / Tahara, Tomomitsu; Arisawa, Tomiyasu; Shibata, Tomoyuki; Nakamura, Masakatsu; Yamashita, Hiromi; Yoshioka, Daisuke; Okubo, Masaaki; Maruyama, Naoko; Kamano, Toshiaki; Kamiya, Yoshio; Fujita, Hiroshi; Nagasaka, Mitsuo; Iwata, Masami; Takahama, Kazuya; Watanabe, Makoto; Nakano, Hiroshi; Hirata, Ichiro.

:: Digestive Diseases and Sciences, 巻 54, 番号 6, 01.06.2009, p. 1247-1252.

研究成果: Article

TY - JOUR

T1 - Effect of RANTES promoter genotype on the severity of intestinal metaplasia in helicobacter pylori-infected Japanese subjects

AU - Tahara, Tomomitsu

AU - Arisawa, Tomiyasu

AU - Shibata, Tomoyuki

AU - Nakamura, Masakatsu

AU - Yamashita, Hiromi

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Maruyama, Naoko

AU - Kamano, Toshiaki

AU - Kamiya, Yoshio

AU - Fujita, Hiroshi

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Takahama, Kazuya

AU - Watanabe, Makoto

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Background A complex interaction of host genetic and environmental factors may be relevant in the development of Helicobacter pylori (H. pylori)-related gastro-duodenal diseases. RANTES is a potent chemoattractant peptide for memory T lymphocytes and eosinophils, and has been shown to be enhanced in H. pylori-infected gastric mucosa. We aimed to clarify the effect of RANTES functional promoter polymorphism on the risk of gastro-duodenal diseases in a Japanese population. Methods Four hundred and eighty-three subjects, comprising 106 gastric ulcer, 52 duodenal ulcer, and 325 non-ulcer subjects, were included in this study. Restriction fragment length polymorphism (RFLP) analysis was performed for polymorphisms at -28 C/G in the RANTES gene promoter region. Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system. Results There were no significant differences in the RANTES promoter genotype distributions among non-ulcer subjects, ulcer patients, and gastric and duodenal ulcers. However, the degree of intestinal metaplasia was significantly lower among G carriers in H. pylori-infected subjects aged 60 years or older (C/C vs. G carriers; 1.28 ± 1.02 vs. 0.83 ± 0.89, P = 0.0357). In addition, we also found that the same genotype held a lower risk of more severe intestinal metaplasia in H. pylori-infected female subjects (C/C vs. G carriers; 0.91 ± 1.03 vs. 0.41 ± 0.73, P = 0.0443). Conclusion The polymorphism of RANTES promoter is not associated with the susceptibility to peptic ulcer diseases, but the -28 G carrier is associated with a reduced risk of developing more severe intestinal metaplasia in H. pylori-positive subjects aged 60 years and older and in female subjects.

AB - Background A complex interaction of host genetic and environmental factors may be relevant in the development of Helicobacter pylori (H. pylori)-related gastro-duodenal diseases. RANTES is a potent chemoattractant peptide for memory T lymphocytes and eosinophils, and has been shown to be enhanced in H. pylori-infected gastric mucosa. We aimed to clarify the effect of RANTES functional promoter polymorphism on the risk of gastro-duodenal diseases in a Japanese population. Methods Four hundred and eighty-three subjects, comprising 106 gastric ulcer, 52 duodenal ulcer, and 325 non-ulcer subjects, were included in this study. Restriction fragment length polymorphism (RFLP) analysis was performed for polymorphisms at -28 C/G in the RANTES gene promoter region. Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system. Results There were no significant differences in the RANTES promoter genotype distributions among non-ulcer subjects, ulcer patients, and gastric and duodenal ulcers. However, the degree of intestinal metaplasia was significantly lower among G carriers in H. pylori-infected subjects aged 60 years or older (C/C vs. G carriers; 1.28 ± 1.02 vs. 0.83 ± 0.89, P = 0.0357). In addition, we also found that the same genotype held a lower risk of more severe intestinal metaplasia in H. pylori-infected female subjects (C/C vs. G carriers; 0.91 ± 1.03 vs. 0.41 ± 0.73, P = 0.0443). Conclusion The polymorphism of RANTES promoter is not associated with the susceptibility to peptic ulcer diseases, but the -28 G carrier is associated with a reduced risk of developing more severe intestinal metaplasia in H. pylori-positive subjects aged 60 years and older and in female subjects.

UR - http://www.scopus.com/inward/record.url?scp=67349223648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349223648&partnerID=8YFLogxK

U2 - 10.1007/s10620-008-0497-2

DO - 10.1007/s10620-008-0497-2

M3 - Article

C2 - 18958622

AN - SCOPUS:67349223648

VL - 54

SP - 1247

EP - 1252

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

IS - 6

ER -