抄録
The effect of salmon calcitonin (SCT) on the lethality of quinolinic acid (QA), an endogenous excitatory amino acid, was investigated in relation to the excitatory amino acid receptor/ion channel complex. SCT increased the LD50 value of QA in a bell-shaped fashion, but the difference was not significant. The non competitive N-methyl-D-aspartate (NMDA) receptor antagonists MK-801 and phencyclidine (PCP) inhibited QA lethality dose- dependently. SCT potentiated the inhibitory effects of these antagonists. The competitive and glycine site antagonists 3-((±)-2-carboxypiperazin-4- yl)propyl-1-phosphonic acid (CPP) and 7-chlorokynurenic acid (7C1K), respectively, inhibited QA lethality in a dose-dependent fashion. SCT did not potentiate the effect of either drug. These results suggest that SCT inhibits NMDA receptors by interacting with Ca ion channel.
本文言語 | 英語 |
---|---|
ページ(範囲) | 191-199 |
ページ数 | 9 |
ジャーナル | Research Communications in Chemical Pathology and Pharmacology |
巻 | 77 |
号 | 2 |
出版ステータス | 出版済み - 1992 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 薬理学、毒性学および薬学一般
- 病理学および法医学
- 毒物学
- 薬理学