Effect of salmon calcitonin on the lethality of quinolinic acid, an excitatory amino acid

Y. Maeda, T. Nakamura, T. Hasegawa, H. Furukawa, T. Nabeshima

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

The effect of salmon calcitonin (SCT) on the lethality of quinolinic acid (QA), an endogenous excitatory amino acid, was investigated in relation to the excitatory amino acid receptor/ion channel complex. SCT increased the LD50 value of QA in a bell-shaped fashion, but the difference was not significant. The non competitive N-methyl-D-aspartate (NMDA) receptor antagonists MK-801 and phencyclidine (PCP) inhibited QA lethality dose- dependently. SCT potentiated the inhibitory effects of these antagonists. The competitive and glycine site antagonists 3-((±)-2-carboxypiperazin-4- yl)propyl-1-phosphonic acid (CPP) and 7-chlorokynurenic acid (7C1K), respectively, inhibited QA lethality in a dose-dependent fashion. SCT did not potentiate the effect of either drug. These results suggest that SCT inhibits NMDA receptors by interacting with Ca ion channel.

本文言語英語
ページ(範囲)191-199
ページ数9
ジャーナルResearch Communications in Chemical Pathology and Pharmacology
77
2
出版ステータス出版済み - 1992
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学、毒性学および薬学一般
  • 病理学および法医学
  • 毒物学
  • 薬理学

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