Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues

Yoshiji Ohta, Hisako Kubo, Koji Yashiro, Koji Ohashi, Yuji Tsuzuki, Naoya Wada, Yasuko Yamamoto, Kuniaki Saito

研究成果: Article

9 引用 (Scopus)

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The aim of this study was to clarify the effect of water-immersion restraint stress (WIRS) on tryptophan (Trp) catabolism through the kynurenine (Kyn) pathway in rat tissues. The tissues of rats subjected to 6 h of WIRS (+WIRS) had increased tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) activities and increased TDO and IDO1 (one of two IDO isozymes in mammals) mRNA expression levels, with decreased Trp and increased Kyn contents in the liver. +WIRS rats had unchanged TDO and IDO activities in the kidney, decreased TDO activity and unchanged IDO activity in the brain, and unchanged IDO activity in the lung and spleen, with increased Kyn content in all of these tissues. Pretreatment of stressed rats with RU486, a glucocorticoid antagonist, attenuated the increased TOD activity, but not the increased IDO activity, with partial recoveries of the decreased Trp and increased Kyn contents in the liver. These results indicate that WIRS enhances hepatic Trp catabolism by inducing both IDO1 and TDO in rats.

元の言語English
ページ(範囲)361-372
ページ数12
ジャーナルJournal of Physiological Sciences
67
発行部数3
DOI
出版物ステータスPublished - 01-05-2017

All Science Journal Classification (ASJC) codes

  • Physiology

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