Effects of σ1 receptor agonist SA4503 and neuroactive steroids on performance in a radial arm maze task in rats

Li Bo Zou, Kiyofumi Yamada, Masashi Sasa, Yoshihiro Nakata, Toshitaka Nabeshima

研究成果: Article

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This study examined the effects of σ1 receptor agonist SA4503 and neuroactive steroids dehydroepiandrosterone sulfate (DHEAS), pregnenolone sulfate (PREGS) and progesterone (PROG) on spatial working and reference memory in a radial arm maze task in rats. The insertion of a 6-min delay between the 2nd and 3rd choices caused a specific decline in working memory, but had no effect on reference memory. This decline in working memory was improved by SA4503, but not by DHEAS, PREGS or PROG. A non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine significantly impaired both working and reference memory in the presence or absence of a delay. The dizocilpine-induced impairments in the presence of a 6-min delay were ameliorated by SA4503, DHEAS and PREGS, whereas PROG had no effect. The beneficial effects of SA4503, DHEAS and PREGS were antagonized by treatment with σ1 receptor antagonist N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)-ethylamine hydrochloride (NE-100). Furthermore, PROG attenuated the ameliorating effects of SA4503, DHEAS and PREGS on dizocilpine-induced memory deficits. These results suggest that σ1 receptors play a significant role in short-term working memory. Furthermore, it is suggested that DHEAS and PREGS ameliorate dizocilpine-induced memory impairments by acting as σ1 receptor agonists, while PROG antagonizes their effects by acting as a σ1 receptor antagonist. Copyright (C) 2000 Elsevier Science Ltd.

元の言語English
ページ(範囲)1617-1627
ページ数11
ジャーナルNeuropharmacology
39
発行部数9
DOI
出版物ステータスPublished - 01-08-2000
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

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