Effects of 5-hydroxytryptamine on defecation in open-field behavior in rats

Tsutomu Kameyama, Masahiko Suzuki, Toshitaka Nabeshima

研究成果: Article

23 引用 (Scopus)

抜粋

An attempt was made to elucidate the role of the serotonergic nervous system in defecation resulting from environmental stimulation in rats. The open-field (OF) test and shuttle box method were used to study the defecation. 5-Hydroxytryptophan (5-HTP) significantly decreased the number of fecal boluses excreted in both emotional situations, namely, in both OF and shuttle box. The fecal excretion was significantly reduced compared with the controls after intraventricular injection of 5-hydroxytryptamine (5-HT). Animals pretreated with p-chlorophenylalanine (pCPA) and 5,6-dihydroxytryptamine (5,6-DHT) tended to show a slight increase in the OF defecation. 5-HTP was equally effective in diminishing the OF performance of pCPA-treated rats. The inhibitory effects of 5-HTP on the defecation were also observed after depletion of biogenic amines by reserpine treatment. Home cage defecation was increased after 5-HTP administration, decreased under pretreatment with pCPA and not influenced by intraventricular injection of 5-HT. These results suggested that the defecation after environmental stimuli was due to a change in 5-HT levels in the brain.

元の言語English
ページ(範囲)875-882
ページ数8
ジャーナルPharmacology, Biochemistry and Behavior
12
発行部数6
DOI
出版物ステータスPublished - 01-01-1980
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

これを引用