TY - JOUR
T1 - Effects of acute and chronic administrations of phencyclidine on the levels of serotonin and 5-hydroxyindoleacetic acid in discrete brain areas of mouse
AU - Nabeshima, Toshitaka
AU - Hiramatsu, Masayuki
AU - Furukawa, Hiroshi
AU - Kameyama, Tsutomu
N1 - Funding Information:
This study was supported in part by the grants-in-aid No. 57570089 from the Ministry of Education, Science and Culture, Japan, the Ishida Foundation and the Mochida Memorial Foundation for Medical and Pharmaceutical Research. We also thank Mr. M. Amano for his technical assistance.
PY - 1985/3/11
Y1 - 1985/3/11
N2 - The effects of phencyclidine (PCP) on the levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in discrete brain areas of mouse were investigated. Following a single administration, PCP significantly increased at 60 min the level of 5-HT but not 5-HIAA in the cortex. However, acute administration of PCP induced no changes of 5-HT and 5-HIAA levels in other brain areas investigated. On the other hand, chronic treatment of PCP produced a significant increase the striatal 5-HT and 5-HIAA levels by about 30% and 20%, respectively. These increased levels were gradually returned to the control levels, and there was no difference of these levels between the control group and the 48 hr withdrawal group. The changes of 5-HT level in the hypothalamus were similar to those in the striatum. These results suggest that the pharmacological actions of PCP and tolerance development to PCP may be related to the functional changes of serotonergic neuronal activity.
AB - The effects of phencyclidine (PCP) on the levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in discrete brain areas of mouse were investigated. Following a single administration, PCP significantly increased at 60 min the level of 5-HT but not 5-HIAA in the cortex. However, acute administration of PCP induced no changes of 5-HT and 5-HIAA levels in other brain areas investigated. On the other hand, chronic treatment of PCP produced a significant increase the striatal 5-HT and 5-HIAA levels by about 30% and 20%, respectively. These increased levels were gradually returned to the control levels, and there was no difference of these levels between the control group and the 48 hr withdrawal group. The changes of 5-HT level in the hypothalamus were similar to those in the striatum. These results suggest that the pharmacological actions of PCP and tolerance development to PCP may be related to the functional changes of serotonergic neuronal activity.
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U2 - 10.1016/0024-3205(85)90389-3
DO - 10.1016/0024-3205(85)90389-3
M3 - Article
C2 - 2579308
AN - SCOPUS:0021869047
SN - 0024-3205
VL - 36
SP - 939
EP - 946
JO - Life Sciences
JF - Life Sciences
IS - 10
ER -