Effects of acute and continuous administration of pentobarbital on phencyclidine response

C. Y. Tai, T. Nabeshima, S. P. Sivam, I. K. Ho

研究成果: Article

6 引用 (Scopus)

抜粋

In mice acutely treated with Na-pentobarbital, the phencyclidine (PCP) induced motor incoordination was significantly enhanced. On the other hand, in mice rendered tolerant to pentobarbital by pentobarbital pellet implantation, PCP induced motor incoordination was markedly attenuated. The biochemical studies also revealed that acute administration of pentobarbital slowed down the rate of decay of PCP in brain and serum. In contrast, the rate of PCP disappearance in pentobarbital tolerant mice was significantly accelerated. It appears that the effects of pentobarbital on PCP response are dependent on its influence on PCP metabolism.

元の言語English
ページ(範囲)239-252
ページ数14
ジャーナルResearch Communications in Substances of Abuse
2
発行部数3
出版物ステータスPublished - 01-01-1981
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

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