Effects of an antithrombin drug in patients with subacute exacerbations of Binswanger disease

Hidekazu Tomimoto, Ichiro Akiguchi, Ryo Ohtani, Hideo Yagi, Satoshi Ogura, Hideaki Wakita

研究成果: Article

5 引用 (Scopus)

抜粋

The blood coagulation system has been shown to be activated in subacute exacerbations of Binswanger disease (BD). In our previous study, the antithrombin drug argatroban ameliorated the neurological exacerbations in a BD patient with antiphospholipid antibody syndrome. We have further examined the therapeutic efficacy of argatroban in 3 BD patients with subacute exacerbations, but without any immune-mediated prothrombotic complications. In 1 out of these 4 patients, treatment with sodium ozagrel, an antiplatelet drug was applied, but was ineffective. In all patients, argatroban treatment reduced the levels of the hemostatic markers, with a corresponding improvement in cognitive dysfunction and gait disorders. These results suggest that the antithrombin effect is true also for BD patients not compromised by the immune-mediated prothrombotic condition.

元の言語English
ページ(範囲)966-969
ページ数4
ジャーナルInternal Medicine
39
発行部数11
DOI
出版物ステータスPublished - 11-2000
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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