Effects of anatomic characteristics of aneurysms on packing density in endovascular coil embolization: analysis of a single center’s experience

Akiyo Sadato, Kazuhide Adachi, Motoharu Hayakawa, Yoko Kato, Yuichi Hirose

研究成果: Article

5 引用 (Scopus)

抄録

When embolizing cerebral aneurysms, dense coil packing may prevent recanalization but this may be influenced by the aneurysm morphology. We have analyzed retrospectively the relationship between anatomic features and the volumetric coil packing density. We analyzed 452 aneurysms in 434 patients treated by coil embolization without stenting, expressing packing density as volume embolization ratio (VER, volume of inserted coils/aneurysm volume). Six morphological variables (neck width, height, maximum diameter, dome to neck ratio (DNR), and aspect ratio), aneurysm location, and whether the aneurysm was ruptured or unruptured were analyzed with respect to dense (VER ≥20 %) or loose (VER <20 %) packing densities, using logistic regression analysis and ROC analysis. Among 452 aneurysms, VERs >20 % were achieved for 272 aneurysms, with a mean VER of 24.7 %. The mean VER of the remaining 180 aneurysms was 15.6 %. In univariate analyses, the predictors for dense packing were having an anterior circulation, DNR, aspect ratio, and neck width. In multivariate analysis, the independent predictors were smaller neck width (odds ratio (OR) 0.8735; 95 % confidence interval (CI) 0.7635–0.9993) and larger aspect ratio (OR 1.6679; 95 % CI 1.0460–2.6594). ROC analysis showed optimal cutoff values for an aspect ratio of 1.35 (sensitivity 69.5 %, specificity 51.7 %) and a neck width of 3.13 mm (sensitivity 51.1 %, specificity 27.8 %). Although dense coil packing is still difficult to achieve in wide-necked aneurysms without the use of stents, packing with VER >20 % is expected to be achieved when the height is 1.35 times larger than the neck width.

元の言語English
ページ(範囲)109-114
ページ数6
ジャーナルNeurosurgical Review
39
発行部数1
DOI
出版物ステータスPublished - 01-01-2016

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Aneurysm
Neck
Odds Ratio
Confidence Intervals
Sensitivity and Specificity
Ruptured Aneurysm
Intracranial Aneurysm
ROC Curve
Stents
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

これを引用

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title = "Effects of anatomic characteristics of aneurysms on packing density in endovascular coil embolization: analysis of a single center’s experience",
abstract = "When embolizing cerebral aneurysms, dense coil packing may prevent recanalization but this may be influenced by the aneurysm morphology. We have analyzed retrospectively the relationship between anatomic features and the volumetric coil packing density. We analyzed 452 aneurysms in 434 patients treated by coil embolization without stenting, expressing packing density as volume embolization ratio (VER, volume of inserted coils/aneurysm volume). Six morphological variables (neck width, height, maximum diameter, dome to neck ratio (DNR), and aspect ratio), aneurysm location, and whether the aneurysm was ruptured or unruptured were analyzed with respect to dense (VER ≥20 {\%}) or loose (VER <20 {\%}) packing densities, using logistic regression analysis and ROC analysis. Among 452 aneurysms, VERs >20 {\%} were achieved for 272 aneurysms, with a mean VER of 24.7 {\%}. The mean VER of the remaining 180 aneurysms was 15.6 {\%}. In univariate analyses, the predictors for dense packing were having an anterior circulation, DNR, aspect ratio, and neck width. In multivariate analysis, the independent predictors were smaller neck width (odds ratio (OR) 0.8735; 95 {\%} confidence interval (CI) 0.7635–0.9993) and larger aspect ratio (OR 1.6679; 95 {\%} CI 1.0460–2.6594). ROC analysis showed optimal cutoff values for an aspect ratio of 1.35 (sensitivity 69.5 {\%}, specificity 51.7 {\%}) and a neck width of 3.13 mm (sensitivity 51.1 {\%}, specificity 27.8 {\%}). Although dense coil packing is still difficult to achieve in wide-necked aneurysms without the use of stents, packing with VER >20 {\%} is expected to be achieved when the height is 1.35 times larger than the neck width.",
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Effects of anatomic characteristics of aneurysms on packing density in endovascular coil embolization : analysis of a single center’s experience. / Sadato, Akiyo; Adachi, Kazuhide; Hayakawa, Motoharu; Kato, Yoko; Hirose, Yuichi.

:: Neurosurgical Review, 巻 39, 番号 1, 01.01.2016, p. 109-114.

研究成果: Article

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AB - When embolizing cerebral aneurysms, dense coil packing may prevent recanalization but this may be influenced by the aneurysm morphology. We have analyzed retrospectively the relationship between anatomic features and the volumetric coil packing density. We analyzed 452 aneurysms in 434 patients treated by coil embolization without stenting, expressing packing density as volume embolization ratio (VER, volume of inserted coils/aneurysm volume). Six morphological variables (neck width, height, maximum diameter, dome to neck ratio (DNR), and aspect ratio), aneurysm location, and whether the aneurysm was ruptured or unruptured were analyzed with respect to dense (VER ≥20 %) or loose (VER <20 %) packing densities, using logistic regression analysis and ROC analysis. Among 452 aneurysms, VERs >20 % were achieved for 272 aneurysms, with a mean VER of 24.7 %. The mean VER of the remaining 180 aneurysms was 15.6 %. In univariate analyses, the predictors for dense packing were having an anterior circulation, DNR, aspect ratio, and neck width. In multivariate analysis, the independent predictors were smaller neck width (odds ratio (OR) 0.8735; 95 % confidence interval (CI) 0.7635–0.9993) and larger aspect ratio (OR 1.6679; 95 % CI 1.0460–2.6594). ROC analysis showed optimal cutoff values for an aspect ratio of 1.35 (sensitivity 69.5 %, specificity 51.7 %) and a neck width of 3.13 mm (sensitivity 51.1 %, specificity 27.8 %). Although dense coil packing is still difficult to achieve in wide-necked aneurysms without the use of stents, packing with VER >20 % is expected to be achieved when the height is 1.35 times larger than the neck width.

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