Effects of assisted reproductive technologies in neonates with indications for surgery (2007-2016)

S. Watanabe, Y. Kondo, A. Naoe, T. Yasui, T. Suzuki, F. Hara, N. Uga, M. Miyata, H. Boda

研究成果: Article

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PURPOSE: Recently, the number of births using assisted reproductive technologies (ART) has increased. An associated increase in the incidence of congenital malformations in babies conceived using this technology has also been reported. Therefore, we aimed to investigate the rate of malformations in babies with neonatal surgical diseases, who were conceived using ART. MATERIALS AND METHODS: Between January 2007 and December 2016, 1737 patients were admitted to our hospital. We analyzed the incidence of congenital cardiac diseases, genetic anomalies, and congenital anomalies of the kidney and urinary tract (CAKUT) in neonates conceived by ART. The X 2 test and logistic regression analysis were used to assess the odds ratios (ORs) for congenital malformations. A P-value < 0.05 indicated statistical significance. RESULTS: The OR for CAKUT was 16.94 for the first-birth neonates conceived using ART, [P < 0.05, AUC (area under the curve) = 0.86]. However, for non-surgery neonates, the OR for CAKUT was 5.99 (P = 0.15, AUC= 0.87), compared to 32.27 (P < 0.05, AUC= 0.93) for parallel conditions in surgery-neonates. CONCLUSION: Neonates conceived using ART are prone to develop CAKUT, which will need surgical treatment. Therefore, more management is necessary for associated malformations in these babies, particularly in cases with CAKUT.

元の言語English
ページ(範囲)379-385
ページ数7
ジャーナルJournal of Neonatal-Perinatal Medicine
11
発行部数4
DOI
出版物ステータスPublished - 01-01-2018

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All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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