Effects of basic fibroblast growth factor on experimental diabetic neuropathy in rats

Mika Nakae, Hideki Kamiya, Keiko Naruse, Naoichi Horio, Yasuki Ito, Ryuichi Mizubayashi, Yoji Hamada, Eitaro Nakashima, Noboru Akiyama, Yasuko Kobayashi, Atsuko Watarai, Nachi Kimura, Masayuki Horiguchi, Yasuhiko Tabata, Yutaka Oiso, Jiro Nakamura

研究成果: Article査読

59 被引用数 (Scopus)

抄録

Basic fibroblast growth factor (bFGF) stimulates angiogenesis and induces neural cell regeneration. We investigated the effects of bFGF on diabetic neuropathy in streptozotocin-induced diabetic rats. Diabetic rats were treated with human recombinant bFGF as follows: 1) intravenous administration, 2) intramuscular injection into thigh and soleus muscles with cross-linked gelatin hydrogel (CGH), and 3) intramuscular injection with saline. Ten or 30 days later, the motor nerve conduction velocity (MNCV) of the sciatic-tibial and caudal nerves, sensitivity to mechanical stimuli, sciatic nerve blood flow (SNBF), and retinal blood flow (RBF) were measured. Delayed MNCV in the sciatic-tibial and caudal nerves, hypoalgesia, and reduced SNBF in diabetic rats were all ameliorated by intravenous administration of bFGF after 10, but not 30, days. Intramuscular injection of bFGF with CGH also improved sciatic-tibial MNCV, hypoalgesia, and SNBF after 10 and 30 days, but caudal MNCV was not improved. However, intramuscular injection of bFGF with saline had no significant effects. bFGF did not significantly alter RBF in either normal or diabetic rats. These observations suggest that bFGF could have therapeutic value for diabetic neuropathy and that CGH could play important roles as a carrier of bFGF.

本文言語English
ページ(範囲)1470-1477
ページ数8
ジャーナルDiabetes
55
5
DOI
出版ステータスPublished - 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 内科学
  • 内分泌学、糖尿病および代謝内科学

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