Effects of Central Muscle Relaxants on the Morphine-induced Straub Tail Reaction

Tsutomu Kameyama, Toshitaka Nabeshima, Makoto Ukai

研究成果: Article

6 引用 (Scopus)

抄録

An investigation of the pharmacological mechanism of the Straub tail reaction (STR) was made of the intracerebral (i.c.) injection of morphine. In addition, the effects of central muscle relaxants on the STR were examined. The STR was elicited by i.c. injection of morphine. Meprobamate, haloperidol, l,3-diphenyl-5-(2-dimethylaminopropion-amide)-pyrazole [difenamizole] and β-(p-chlorophenyl)-γ-aminobutyric acid [baclofen] apparently decreased the STR by systemic administration. In mice injected i.c. with difenamizole or baclofen, moreover, the STR was noticeably inhibited. Especially, baclofen decreased the STR in the approximate one-thousandth of the dose by systemic administration. Thus it appears that the central nervous system may have a profound significance for the manifestation of the STR due to morphine in mice.

元の言語English
ページ(範囲)1837-1839
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
25
発行部数7
DOI
出版物ステータスPublished - 01-01-1977

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Central Muscle Relaxants
Baclofen
Morphine
Tail
Meprobamate
Aminobutyrates
Neurology
Haloperidol
Amides
Injections
Central Nervous System
Pharmacology
difenamizole

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

これを引用

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abstract = "An investigation of the pharmacological mechanism of the Straub tail reaction (STR) was made of the intracerebral (i.c.) injection of morphine. In addition, the effects of central muscle relaxants on the STR were examined. The STR was elicited by i.c. injection of morphine. Meprobamate, haloperidol, l,3-diphenyl-5-(2-dimethylaminopropion-amide)-pyrazole [difenamizole] and β-(p-chlorophenyl)-γ-aminobutyric acid [baclofen] apparently decreased the STR by systemic administration. In mice injected i.c. with difenamizole or baclofen, moreover, the STR was noticeably inhibited. Especially, baclofen decreased the STR in the approximate one-thousandth of the dose by systemic administration. Thus it appears that the central nervous system may have a profound significance for the manifestation of the STR due to morphine in mice.",
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Effects of Central Muscle Relaxants on the Morphine-induced Straub Tail Reaction. / Kameyama, Tsutomu; Nabeshima, Toshitaka; Ukai, Makoto.

:: Chemical and Pharmaceutical Bulletin, 巻 25, 番号 7, 01.01.1977, p. 1837-1839.

研究成果: Article

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AU - Kameyama, Tsutomu

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AU - Ukai, Makoto

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N2 - An investigation of the pharmacological mechanism of the Straub tail reaction (STR) was made of the intracerebral (i.c.) injection of morphine. In addition, the effects of central muscle relaxants on the STR were examined. The STR was elicited by i.c. injection of morphine. Meprobamate, haloperidol, l,3-diphenyl-5-(2-dimethylaminopropion-amide)-pyrazole [difenamizole] and β-(p-chlorophenyl)-γ-aminobutyric acid [baclofen] apparently decreased the STR by systemic administration. In mice injected i.c. with difenamizole or baclofen, moreover, the STR was noticeably inhibited. Especially, baclofen decreased the STR in the approximate one-thousandth of the dose by systemic administration. Thus it appears that the central nervous system may have a profound significance for the manifestation of the STR due to morphine in mice.

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