Effects of cepharanthin on neutrophil chemotaxis, phagocytosis, and reactive oxygen species generation

H. Akamatsu, J. Komura, Y. Asada, Y. Niwa

研究成果: Article査読

10 被引用数 (Scopus)

抄録

The effects of cepharanthin on inflammatory parameters such as neutrophi1 chemotaxis, phagocytosis and reactive oxygen species (ROS) generation, were examined. Cepharanthin significantly decreased the levels of O2-, H2O2, and OH· generated by neutrophils. H2O2 and OH· generated in a cell-free, xanthine-xanthine oxidase system were also reduced in the presence of cepharanthin. However, the drug did not affect neutrophil chemotaxis or phagocytosis. The present study indicates that cepharanthin is an effective ROS scavenger, exerting its anti-inflammatory action by reducing the potent ROS species excessively generated in tissues and organs, especially at the sites of inflammation.

本文言語English
ページ(範囲)643-648
ページ数6
ジャーナルJournal of Dermatology
18
11
DOI
出版ステータスPublished - 1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 皮膚病学

フィンガープリント

「Effects of cepharanthin on neutrophil chemotaxis, phagocytosis, and reactive oxygen species generation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル