Effects of digit tissue on cell death and ectopic cartilage formation in the interdigital zone in chick leg buds

Minoru Omi, Hiroyuki Ide

研究成果: Article査読

7 被引用数 (Scopus)

抄録

In developing chick leg buds, large-scale cell death occurs in the interdigital zone, which is responsible for the separation of digits from each other. Ectopic cartilage formation is known to occur upon removal of the chondrogenic digit tissue of the leg bud. To examine the mechanisms of ectopic cartilage formation in the interdigital cell death region, we performed the following operations on stage 28-29 leg buds: (i) removal of the digit-forming area; (ii) incision between the interdigital zone and digit region; (iii) insertion of an aluminum barrier into the interdigital zone; and (iv) insertion of a permeable Nuclepore filter into the interdigital zone. In all cases, the inhibition of cell death and/or the formation of ectopic cartilage in the interdigital zone were observed, although the frequency of the inhibition of cell death and the formation of ectopic cartilage varied, depending upon the position where the operations were performed. These results suggest that cell death and cell differentiation in the interdigital zone may be controlled by some factor(s) from digit cartilage.

本文言語English
ページ(範囲)419-428
ページ数10
ジャーナルDevelopment Growth and Differentiation
38
4
DOI
出版ステータスPublished - 1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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