Effects of DM-9384, a cyclic derivative of GABA, on amnesia and decreases in GABA(A) and muscarinic receptors induced by cycloheximide

T. Nabeshima, K. Tohyama, K. Murase, S. Ishihara, T. Kameyama, T. Yamasaki, S. Hatanaka, H. Kojima, T. Sakurai, Y. Takasu, T. Shiotani

研究成果: Article

57 引用 (Scopus)

抄録

The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl)-acetamide [DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre- and post-training and pre-retention test administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. Aniracetam, another cyclic derivative of GABA, also showed antiamnesic effects. Scopolamine, a muscarinic ACh receptor antagonist, and the GABA antagonists, picrotoxin and bicuculline, all antagonized the antiamnesic effects of DM-9384. CXM decreased the number of GABA(A) and muscarinic ACh receptor binding sites. DM-9384 not only inhibited this effect but actually increased the latter. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with GABAergic and AChergic neuronal systems and enhancing protein synthesis in the brain.

元の言語English
ページ(範囲)271-275
ページ数5
ジャーナルJournal of Pharmacology and Experimental Therapeutics
257
発行部数1
出版物ステータスPublished - 01-01-1991

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Amnesia
Muscarinic Receptors
GABA-A Receptors
Cycloheximide
gamma-Aminobutyric Acid
aniracetam
Cholinergic Receptors
GABA Antagonists
Picrotoxin
Scopolamine Hydrobromide
Bicuculline
Animal Models
Binding Sites
nefiracetam
Brain
Proteins

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

Nabeshima, T. ; Tohyama, K. ; Murase, K. ; Ishihara, S. ; Kameyama, T. ; Yamasaki, T. ; Hatanaka, S. ; Kojima, H. ; Sakurai, T. ; Takasu, Y. ; Shiotani, T. / Effects of DM-9384, a cyclic derivative of GABA, on amnesia and decreases in GABA(A) and muscarinic receptors induced by cycloheximide. :: Journal of Pharmacology and Experimental Therapeutics. 1991 ; 巻 257, 番号 1. pp. 271-275.
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abstract = "The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl)-acetamide [DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre- and post-training and pre-retention test administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. Aniracetam, another cyclic derivative of GABA, also showed antiamnesic effects. Scopolamine, a muscarinic ACh receptor antagonist, and the GABA antagonists, picrotoxin and bicuculline, all antagonized the antiamnesic effects of DM-9384. CXM decreased the number of GABA(A) and muscarinic ACh receptor binding sites. DM-9384 not only inhibited this effect but actually increased the latter. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with GABAergic and AChergic neuronal systems and enhancing protein synthesis in the brain.",
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Nabeshima, T, Tohyama, K, Murase, K, Ishihara, S, Kameyama, T, Yamasaki, T, Hatanaka, S, Kojima, H, Sakurai, T, Takasu, Y & Shiotani, T 1991, 'Effects of DM-9384, a cyclic derivative of GABA, on amnesia and decreases in GABA(A) and muscarinic receptors induced by cycloheximide', Journal of Pharmacology and Experimental Therapeutics, 巻. 257, 番号 1, pp. 271-275.

Effects of DM-9384, a cyclic derivative of GABA, on amnesia and decreases in GABA(A) and muscarinic receptors induced by cycloheximide. / Nabeshima, T.; Tohyama, K.; Murase, K.; Ishihara, S.; Kameyama, T.; Yamasaki, T.; Hatanaka, S.; Kojima, H.; Sakurai, T.; Takasu, Y.; Shiotani, T.

:: Journal of Pharmacology and Experimental Therapeutics, 巻 257, 番号 1, 01.01.1991, p. 271-275.

研究成果: Article

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T1 - Effects of DM-9384, a cyclic derivative of GABA, on amnesia and decreases in GABA(A) and muscarinic receptors induced by cycloheximide

AU - Nabeshima, T.

AU - Tohyama, K.

AU - Murase, K.

AU - Ishihara, S.

AU - Kameyama, T.

AU - Yamasaki, T.

AU - Hatanaka, S.

AU - Kojima, H.

AU - Sakurai, T.

AU - Takasu, Y.

AU - Shiotani, T.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl)-acetamide [DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre- and post-training and pre-retention test administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. Aniracetam, another cyclic derivative of GABA, also showed antiamnesic effects. Scopolamine, a muscarinic ACh receptor antagonist, and the GABA antagonists, picrotoxin and bicuculline, all antagonized the antiamnesic effects of DM-9384. CXM decreased the number of GABA(A) and muscarinic ACh receptor binding sites. DM-9384 not only inhibited this effect but actually increased the latter. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with GABAergic and AChergic neuronal systems and enhancing protein synthesis in the brain.

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