Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice

Toshitaka Nabeshima, Keiko Tohyama, Tsutomu Kameyama

研究成果: Article査読

27 被引用数 (Scopus)

抄録

The effects of N- (2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative. Pretraining administration of DM-9384 attenuated ethanol- and CDP-induced amnesia, whereas aniracetam failed to do so. The effects of DM-9384 on CDP-induced amnesia were antagonized by bicuculline, a GABAA receptor antagonist, but not by scopolamine, a muscarinic acethylcholine receptor antagonist and flumazenil, a benzodiazepine receptor antagonist. These results suggest that DM-9384 attenuates CDP-induced amnesia by interacting with the GABAergic neuronal system.

本文言語English
ページ(範囲)233-236
ページ数4
ジャーナルPharmacology, Biochemistry and Behavior
36
2
DOI
出版ステータスPublished - 06-1990

All Science Journal Classification (ASJC) codes

  • 生化学
  • 毒物学
  • 薬理学
  • 臨床生化学
  • 生物学的精神医学
  • 行動神経科学

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