Effects of Dorsal Column Spinal Cord Stimulation (DCS) on Reversibility of Neuronal Function—Experience of Treatment for Vegetative States

TETSUO KANNO, YOSHIFUMI KAMEL, TETSUYA YOKOYAMA, MOTOI SHODA, HIDEAKI TANJI, MASAHIKO NOMURA

研究成果: Article査読

47 被引用数 (Scopus)

抄録

We have reported that DCS (dorsal column stimulation) improves the clinical symptoms of cases in persistent vegetative states. Since then, we have accumulated 23 cases who have been treated by DCS. We describe the clinical EEG, rCBF, and biochemical changes in cerebrospinal fluid (CSF) caused by DCS in patients in persistent vegetative states; (1) eight of these cases showed good clinical improvement; (2) most patients were young and the CTscan did not show large, diffuse, definite or bilateral low density areas in cortex, brainstem of thalmus; (3) neurostimulation increased rCBF (cerebral blood flow) in many parts of the brain in cases with vegetative states; blood flow increased in the cerebrum, cerebellum and brainstem; (4) neurostimuiation enhanced the metabolism of catecholamines in CSF, NE, DA, DOPAC, HVA, and 5H1AA increased, but 3MT and 5HT decreased in CSF. DCS increased rCBF, enhanced the metabolism of catecholamines in CSF, and improved the EEG in patients in persistent vegetative states.

本文言語English
ページ(範囲)733-738
ページ数6
ジャーナルPACE - Pacing and Clinical Electrophysiology
12
4
DOI
出版ステータスPublished - 04-1989

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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