Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

E. J. Shin, J. M. Kim, X. K.T. Nguyen, T. T.L. Nguyen, S. Y. Lee, J. H. Jung, M. J. Kim, W. K. Whang, K. Yamada, T. Nabeshima, H. C. Kim

研究成果: ジャーナルへの寄稿学術論文査読

7 被引用数 (Scopus)

抄録

It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.

本文言語英語
ページ(範囲)247-250
ページ数4
ジャーナルCurrent Neuropharmacology
9
1
DOI
出版ステータス出版済み - 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生
  • 薬理学(医学)

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