Effects of metaphit on phencyclidine and serotonin2 receptors

Toshitaka Nabeshima, Keiko Tohyama, Akihiro Noda, Yohko Maeda, Masayuki Hiramatsu, Silvia M. Harrer, Tsutomu Kameyama, Hiroshi Furukawa, Arthur E. Jacobson, Kenner C. Rice

研究成果: Article

10 引用 (Scopus)


We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.

ジャーナルNeuroscience Letters
出版物ステータスPublished - 31-07-1989

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

フィンガープリント Effects of metaphit on phencyclidine and serotonin<sub>2</sub> receptors' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Nabeshima, T., Tohyama, K., Noda, A., Maeda, Y., Hiramatsu, M., Harrer, S. M., Kameyama, T., Furukawa, H., Jacobson, A. E., & Rice, K. C. (1989). Effects of metaphit on phencyclidine and serotonin2 receptors. Neuroscience Letters, 102(2-3), 303-308. https://doi.org/10.1016/0304-3940(89)90096-7