抄録
The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.
本文言語 | 英語 |
---|---|
ページ(範囲) | 103-111 |
ページ数 | 9 |
ジャーナル | Journal of Neural Transmission |
巻 | 90 |
号 | 2 |
DOI | |
出版ステータス | 出版済み - 06-1992 |
All Science Journal Classification (ASJC) codes
- 神経学
- 臨床神経学
- 精神医学および精神衛生
- 生物学的精神医学