抄録
The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 103-111 |
| ページ数 | 9 |
| ジャーナル | Journal of Neural Transmission |
| 巻 | 90 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | Published - 01-06-1992 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
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Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide. / Shiotani, T.; Tohyama, K.; Murase, K.; Ishihara, S.; Kameyama, T.; Yamasaki, T.; Hatanaka, S.; Kojima, H.; Takasu, Y.; Nabeshima, Toshitaka.
：: Journal of Neural Transmission, 巻 90, 番号 2, 01.06.1992, p. 103-111.研究成果: Article
TY - JOUR
T1 - Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide
AU - Shiotani, T.
AU - Tohyama, K.
AU - Murase, K.
AU - Ishihara, S.
AU - Kameyama, T.
AU - Yamasaki, T.
AU - Hatanaka, S.
AU - Kojima, H.
AU - Takasu, Y.
AU - Nabeshima, Toshitaka
PY - 1992/6/1
Y1 - 1992/6/1
N2 - The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.
AB - The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.
UR - http://www.scopus.com/inward/record.url?scp=0026564189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026564189&partnerID=8YFLogxK
U2 - 10.1007/BF01250792
DO - 10.1007/BF01250792
M3 - Article
VL - 90
SP - 103
EP - 111
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
SN - 0300-9564
IS - 2
ER -