Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

T. Shiotani, K. Tohyama, K. Murase, S. Ishihara, T. Kameyama, T. Yamasaki, S. Hatanaka, H. Kojima, Y. Takasu, Toshitaka Nabeshima

研究成果: Article

11 引用 (Scopus)

抄録

The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

元の言語English
ページ(範囲)103-111
ページ数9
ジャーナルJournal of Neural Transmission
90
発行部数2
DOI
出版物ステータスPublished - 01-06-1992

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Amnesia
Cycloheximide
Choline O-Acetyltransferase
Cerebral Cortex
gamma-Aminobutyric Acid
Animal Models
nefiracetam
Brain
Proteins

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

これを引用

Shiotani, T. ; Tohyama, K. ; Murase, K. ; Ishihara, S. ; Kameyama, T. ; Yamasaki, T. ; Hatanaka, S. ; Kojima, H. ; Takasu, Y. ; Nabeshima, Toshitaka. / Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide. :: Journal of Neural Transmission. 1992 ; 巻 90, 番号 2. pp. 103-111.
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abstract = "The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.",
author = "T. Shiotani and K. Tohyama and K. Murase and S. Ishihara and T. Kameyama and T. Yamasaki and S. Hatanaka and H. Kojima and Y. Takasu and Toshitaka Nabeshima",
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Shiotani, T, Tohyama, K, Murase, K, Ishihara, S, Kameyama, T, Yamasaki, T, Hatanaka, S, Kojima, H, Takasu, Y & Nabeshima, T 1992, 'Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide', Journal of Neural Transmission, 巻. 90, 番号 2, pp. 103-111. https://doi.org/10.1007/BF01250792

Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide. / Shiotani, T.; Tohyama, K.; Murase, K.; Ishihara, S.; Kameyama, T.; Yamasaki, T.; Hatanaka, S.; Kojima, H.; Takasu, Y.; Nabeshima, Toshitaka.

:: Journal of Neural Transmission, 巻 90, 番号 2, 01.06.1992, p. 103-111.

研究成果: Article

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T1 - Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

AU - Shiotani, T.

AU - Tohyama, K.

AU - Murase, K.

AU - Ishihara, S.

AU - Kameyama, T.

AU - Yamasaki, T.

AU - Hatanaka, S.

AU - Kojima, H.

AU - Takasu, Y.

AU - Nabeshima, Toshitaka

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AB - The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

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