Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

T. Shiotani; K. Tohyama; K. Murase; S. Ishihara; T. Kameyama; T. Yamasaki; S. Hatanaka; H. Kojima; Y. Takasu; T. Nabeshima

doi:10.1007/BF01250792

Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

T. Shiotani
, K. Tohyama
, K. Murase
, S. Ishihara
, T. Kameyama
, T. Yamasaki
, S. Hatanaka
, H. Kojima
, Y. Takasu
, T. Nabeshima

医学部・救急医学・総合内科学

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

抄録

The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

本文言語	英語
ページ（範囲）	103-111
ページ数	9
ジャーナル	Journal of Neural Transmission
巻	90
号	2
DOI	https://doi.org/10.1007/BF01250792
出版ステータス	出版済み - 06-1992

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この成果は、次の持続可能な開発目標に貢献しています

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All Science Journal Classification (ASJC) codes

神経学
臨床神経学
精神医学および精神衛生
生物学的精神医学

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10.1007/BF01250792

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引用スタイル

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title = "Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide",

abstract = "The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.",

author = "T. Shiotani and K. Tohyama and K. Murase and S. Ishihara and T. Kameyama and T. Yamasaki and S. Hatanaka and H. Kojima and Y. Takasu and T. Nabeshima",

year = "1992",

month = jun,

doi = "10.1007/BF01250792",

language = "English",

volume = "90",

pages = "103--111",

journal = "Journal of Neural Transmission",

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TY - JOUR

T1 - Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

AU - Shiotani, T.

AU - Tohyama, K.

AU - Murase, K.

AU - Ishihara, S.

AU - Kameyama, T.

AU - Yamasaki, T.

AU - Hatanaka, S.

AU - Kojima, H.

AU - Takasu, Y.

AU - Nabeshima, T.

PY - 1992/6

Y1 - 1992/6

N2 - The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

AB - The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

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UR - https://www.scopus.com/pages/publications/0026564189#tab=citedBy

U2 - 10.1007/BF01250792

DO - 10.1007/BF01250792

M3 - Article

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AN - SCOPUS:0026564189

SN - 0300-9564

VL - 90

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JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 2

ER -

Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

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UN SDG

All Science Journal Classification (ASJC) codes

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