Effects of nefiracetam on drug-induced impairment of latent learning in mice in a water finding task

Toshitaka Nabeshima, Shinobu Nakayama, Kenji Ichihara, Kiyofumi Yamada, Tadashi Shiotani, Takaaki Hasegawa

研究成果: Article査読

29 被引用数 (Scopus)

抄録

We investigated the effects of nefiracetam (DM-9384), a pyrrolidone derivative, on chlordiazepoxide-, apomorphine-, and methamphetamine-induced impairment of latent learning in a water finding test in mice. Pretreatment with nefiracetam reversed the inhibitory effects of chlordiazepoxide and apomorphine, but not those of methamphetamine, on latent learning. The ameliorative effects of nefiracetam on apomorphine-induced, but not chlordiazepoxide-induced impairment of latent learning were antagonized by scopolamine. These results provide further evidence that nefiracetam has anti-amnesic effects. Further, it is suggested that the cholinergic neuronal system may be involved in the ameliorative effects exerted by nefiracetam on apomorphine-induced impairment of latent learning.

本文言語English
ページ(範囲)57-65
ページ数9
ジャーナルEuropean Journal of Pharmacology
255
1-3
DOI
出版ステータスPublished - 01-04-1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学

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