TY - CHAP
T1 - Effects of Nobiletin in Animal Models of Cognitive Impairment
T2 - Current Insights and Future Perspectives
AU - Nakajima, Akira
AU - Ohizumi, Yasushi
AU - Yamada, Kiyofumi
N1 - Publisher Copyright:
© 2017 John Wiley & Sons, Inc. All rights reserved.
PY - 2017/1/2
Y1 - 2017/1/2
N2 - Alzheimer's disease (AD) is characterized by the progressive decline of cognitive function and has a devastating impact on the whole of society. Despite intensive laboratory and clinical research, no pharmacological options are currently available for the prevention and effective long-term treatment of AD. Nobiletin, a polymethoxylated flavone from the peel of Citrus depressa, has been demonstrated to exhibit memory-improving effects in various animal models of AD, including a triple transgenic mouse model (3XTg-AD). Furthermore, it exerts a wide range of beneficial effects against pathological features of AD, including amyloid beta (Aβ) pathology, hyperphosphorylation of tau, oxidative stress, cholinergic neurodegeneration, and dysfunction of synaptic plasticity-related signaling. These results suggest that this natural compound has the potential to become a novel drug for the treatment and prevention of AD.
AB - Alzheimer's disease (AD) is characterized by the progressive decline of cognitive function and has a devastating impact on the whole of society. Despite intensive laboratory and clinical research, no pharmacological options are currently available for the prevention and effective long-term treatment of AD. Nobiletin, a polymethoxylated flavone from the peel of Citrus depressa, has been demonstrated to exhibit memory-improving effects in various animal models of AD, including a triple transgenic mouse model (3XTg-AD). Furthermore, it exerts a wide range of beneficial effects against pathological features of AD, including amyloid beta (Aβ) pathology, hyperphosphorylation of tau, oxidative stress, cholinergic neurodegeneration, and dysfunction of synaptic plasticity-related signaling. These results suggest that this natural compound has the potential to become a novel drug for the treatment and prevention of AD.
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U2 - 10.1002/9781119155195.ch21
DO - 10.1002/9781119155195.ch21
M3 - Chapter
AN - SCOPUS:85019871262
SN - 9781119155140
SP - 421
EP - 433
BT - Neuroprotective Effects of Phytochemicals in Neurological Disorders
PB - wiley
ER -