Effects of Nobiletin in Animal Models of Cognitive Impairment: Current Insights and Future Perspectives

Akira Nakajima, Yasushi Ohizumi, Kiyofumi Yamada

研究成果: 書籍/レポート タイプへの寄稿

抄録

Alzheimer's disease (AD) is characterized by the progressive decline of cognitive function and has a devastating impact on the whole of society. Despite intensive laboratory and clinical research, no pharmacological options are currently available for the prevention and effective long-term treatment of AD. Nobiletin, a polymethoxylated flavone from the peel of Citrus depressa, has been demonstrated to exhibit memory-improving effects in various animal models of AD, including a triple transgenic mouse model (3XTg-AD). Furthermore, it exerts a wide range of beneficial effects against pathological features of AD, including amyloid beta (Aβ) pathology, hyperphosphorylation of tau, oxidative stress, cholinergic neurodegeneration, and dysfunction of synaptic plasticity-related signaling. These results suggest that this natural compound has the potential to become a novel drug for the treatment and prevention of AD.

本文言語英語
ホスト出版物のタイトルNeuroprotective Effects of Phytochemicals in Neurological Disorders
出版社wiley
ページ421-433
ページ数13
ISBN(電子版)9781119155195
ISBN(印刷版)9781119155140
DOI
出版ステータス出版済み - 02-01-2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学一般
  • 神経科学一般

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