Effects of oral administration of chlordecone and mirex on brain biogenic amines in mice

K. Fujimori, Toshitaka Nabeshima, I. K. Ho, H. M. Mehendale

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and the 5-HT metabolite, 5-hydroxyindole acetic acid (5-HIAA) were determined in brains of mice after daily oral administration of 10, 25 or 50 mg/kg of chlordecone or mirex until mortality occurred. Significant decreases in whole brain and striatal DA levels were observed in chlordecone-treated mice exhibiting tremors. Mirex had no effect at the 3 doses tested. In mice treated with chlordecone or mirex, the 5-HT levels were elevated only in animals exhibiting severe tremors or diarrhea, respectively. NE levels were not altered by chlordecone or mirex. These results suggest that chlordecone-induced neurotoxicity may be due in part to a decrease in the inhibitory state of dopamine neurons.

本文言語English
ページ(範囲)143-148
ページ数6
ジャーナルNeuroToxicology
3
2
出版ステータスPublished - 01-12-1982
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 毒物学

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