Effects of Partial Splenic Embolization of Severe Functional Disturbances of Coagulation-Fibrinolysis System Associated with Liver Cirrhosis and its Application on Hepatectomy for Hepatocellular Carcinoma

Hajime Yokoi, Kentaro Yamagiwa, Takashi Higashiguchi, Takashi Noguchi, Yoshifumi Kawarada, Ryuji Mizumoto

研究成果: Article

3 引用 (Scopus)

抄録

The present clinical study was undertaken to evaluate the effects of partial splenic embolization (PSE) on hypersplenism with severe functional disturbances of the coagulation-fibrinolysis system associated with liver cirrhosis. This was an attempt to achieve radical hepatectomy for hepatocellular carcinoma. [1] Effects of PSE on hypersplenism associated with liver cirrhosis: Functional disturbances of coagulation-fibrinolysis system in 16 patients with liver cirrhosis improved after PSE, but it had disappeared within one month ater PSE in patients with a splenic infarction area of less than 70%, while it had been maintained even after one year in patients with an infarction area of more than 70% with shrinkage of splenic volume. However, 2 out of 5 patients with an infarction area of more than 90% developed splenic cyst. [2] Results of hepatectomy for hepatocellular carcinoma: Among 9 patients with potential DIC risk according to our criteria, 4 (44.4%) developed DIC and died of liver failure within 6 months after hepatectomy without PSE, whereas all 9 patients undergoing hepatectomy after PSE, including 6 cases with potential DIC risk, had an uneventful postoperative course with well maintained function of the coagulation-fibrinolysis system and lessened splenic volume one year after hepatectomy. And they showed appreciable hepatic regeneration.

元の言語English
ページ(範囲)127-139
ページ数13
ジャーナルThe Japanese Journal Of Gastroenterological Surgery
23
発行部数2
DOI
出版物ステータスPublished - 01-02-1988

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Hepatectomy
Fibrinolysis
Liver Cirrhosis
Hepatocellular Carcinoma
Dacarbazine
Hypersplenism
Infarction
Splenic Infarction
Liver Failure
Cysts
Regeneration
Liver

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology

これを引用

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abstract = "The present clinical study was undertaken to evaluate the effects of partial splenic embolization (PSE) on hypersplenism with severe functional disturbances of the coagulation-fibrinolysis system associated with liver cirrhosis. This was an attempt to achieve radical hepatectomy for hepatocellular carcinoma. [1] Effects of PSE on hypersplenism associated with liver cirrhosis: Functional disturbances of coagulation-fibrinolysis system in 16 patients with liver cirrhosis improved after PSE, but it had disappeared within one month ater PSE in patients with a splenic infarction area of less than 70{\%}, while it had been maintained even after one year in patients with an infarction area of more than 70{\%} with shrinkage of splenic volume. However, 2 out of 5 patients with an infarction area of more than 90{\%} developed splenic cyst. [2] Results of hepatectomy for hepatocellular carcinoma: Among 9 patients with potential DIC risk according to our criteria, 4 (44.4{\%}) developed DIC and died of liver failure within 6 months after hepatectomy without PSE, whereas all 9 patients undergoing hepatectomy after PSE, including 6 cases with potential DIC risk, had an uneventful postoperative course with well maintained function of the coagulation-fibrinolysis system and lessened splenic volume one year after hepatectomy. And they showed appreciable hepatic regeneration.",
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AU - Higashiguchi, Takashi

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AU - Kawarada, Yoshifumi

AU - Mizumoto, Ryuji

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