Effects of polaprezinc (Z-103) on chronic ulcer model induced by Fe2+-ascorbic acid in rats

T. Yoneta, H. Morita, Y. Hori, K. Seto, H. Yamada, T. Takemasa, Y. Ikeda, Y. Naito, T. Yoshikawa

研究成果: Article査読

2 被引用数 (Scopus)

抄録

In order to determine the role of antioxidative effects of polaprezinc (Z-103) in the mechanism of its anti-ulcer effects, a new chronic ulcer model was produced using Fe2+-ascorbic acid, a free radical generation system, and experiments were conducted to determine characteristics of this model and effects of Z-103 on it. Chronic ulcers were produced by locally injecting 0.4 M Fe2+-ascorbic acid under the serosa in the anterior wall of the glandular stomach. In this model, 3 mg/kg of Z-103 significantly reduced the ulcer area on the 10th and 14th days, and its effects were dose-dependent on the 14th day. In this model, 100 mg/kg of cetraxate HCl and 10 μg/kg of 16, 16-dimethylprostaglandin E2 had almost no effects. However, 200 mg/kg of cimetidine, an H2-antagonist, markedly reduced the ulcer area on the 14th day. On the 11th day, significant increases in TBA-reactive substances and myeloperoxidase activity were observed in ulcerative areas compared to nonulcerative areas. Z-103 (1-10 mg/kg) dose-dependently decreased them, and its effects were significant at 10 mg/kg. While L-carnosine, a related substance of Z-103, had no effect, zinc sulfate and a combination of zinc sulfate and L-carnosine reduced the ulcer area on the 14th day at a dose epuivalent to 3 mg/kg of Z-103. From these findings, free radicals and acid secretion were thought to be involved in the development of chronic ulcer in this model. Z-103 showed marked efficacy in this model, and its effects were thought to be mainly attributable to its antioxidative effects and promoting action of the wound healing of this compound.

本文言語English
ページ(範囲)393-399
ページ数7
ジャーナルTherapeutic Research
15
11
出版ステータスPublished - 01-01-1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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