Effects of Prenatal Administration of Phencyclidine on the Learning and Memory Processes of Rat Offspring

Toshitaka Nabeshima, Masayuki Hiramatsu, Kazumasa Yamaguchi, Masami Kasugai, Kimie Ishizaki, Kazuaki Kawashima, Kaname Itoh, Shin Ichi Ogawa, Akira Katoh, Hiroshi Furukawa, Tsutomu Kameyama

研究成果: Article

7 引用 (Scopus)

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The effects of prenatal administration of phencyclidine (PCP) on the learning and memory processes of rat offspring were investigated at doses below the level for producing malformations. The offspring prenatally treated with PCP (10 or 20 mg/kg) on days 7 to 17, as well as on days 7 to 21 of gestation, showed disruption of the acquisition of passive avoidance response and pole-climbing avoidance response at the ages of 4 and 7 weeks, respectively. The brain weight of the offspring prenatally treated with PCP was significantly decreased. These results suggest that prenatal PCP administration impairs learning and memory processes of passive and active avoidance tasks and that more attention should be given to the developmental toxicity of PCP.

元の言語English
ページ(範囲)816-823
ページ数8
ジャーナルJournal of Pharmacobio-Dynamics
11
発行部数12
DOI
出版物ステータスPublished - 01-02-1988
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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    Nabeshima, T., Hiramatsu, M., Yamaguchi, K., Kasugai, M., Ishizaki, K., Kawashima, K., Itoh, K., Ogawa, S. I., Katoh, A., Furukawa, H., & Kameyama, T. (1988). Effects of Prenatal Administration of Phencyclidine on the Learning and Memory Processes of Rat Offspring. Journal of Pharmacobio-Dynamics, 11(12), 816-823. https://doi.org/10.1248/bpb1978.11.816