Effects of roxithromycin on adhesion molecules expressed on endothelial cells of the dermal microvasculature

H. Akamatsu, M. Yamawaki, T. Horio

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The objective of the study was to investigate the pharmacological action of roxithromycin, an oral macrolide antibiotic. The effects of roxithromycin on the cytokine-induced expression of endothelial leukocyte adhesion molecule (E-selectin) and intracellular adhesion molecule (ICAM)-1 on endothelial cells of the dermal microvasculature were investigated in vitro using flow cytometry. Roxithromycin at a concentration of 0.5 μg/ml, which is lower than the therapeutic plasma concentration (ordinary daily dose, 150 - 300 mg), significantly inhibited the expression of E-selectin and ICAM-1 on endothelial cells of the dermal microvasculature induced by tumour necrosis factor-α. We conclude that roxithromycin may exert its antiinflammatory action by inhibition of the in vivo expression of adhesion molecules on dermal microvascular endothelial cells.

本文言語English
ページ(範囲)523-527
ページ数5
ジャーナルJournal of International Medical Research
29
6
DOI
出版ステータスPublished - 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

フィンガープリント 「Effects of roxithromycin on adhesion molecules expressed on endothelial cells of the dermal microvasculature」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル