Effects of sodium houttuyfonate on phosphorylation of CaMK II, CREB and ERK 1/2 and expression of c-Fos in macrophages

Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Toshitaka Nabeshima, Qinghai Yu

研究成果: Article査読

18 被引用数 (Scopus)

抄録

The purpose of this research is to investigate the effects of sodium houttuyfonate on the phosphorylation of CaMK II, CREB and ERK 1/2, and the expression of c-Fos. Macrophages were cultured in vitro with or without sodium houttuyfonate in the culture medium. After cell culture, macrophages were lysed and the lysate of the macrophages was collected for analysis. Western-blotting method was adopted to investigate the phosphorylation or the expression of these signal elements. It was found in this research that the phosphorylation levels of CaMK II and CREB and the expression of c-Fos protein in macrophages were increased by sodium houttuyfonate treatment; however, the phosphorylation level of ERK 1/2 was not affected by the treatment.

本文言語English
ページ(範囲)1083-1088
ページ数6
ジャーナルInternational Immunopharmacology
4
8
DOI
出版ステータスPublished - 08-2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 薬理学

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