Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene

Toshitaka Nabeshima, A. Itoh, K. Kobayashi, S. Morita, T. Mizuguchi, H. Sawada, A. Nitta, T. Hasegawa, K. Hayashi, T. Nagatsu

研究成果: Article

11 引用 (Scopus)

抄録

We produced transgenic (Tg) mice carrying the human tyrosine hydroxylase (TH) gene. To investigate differences in the dopaminergic (DAergic) neuronal activity between the Tg and nTg mice, we examined changes in the locomotor activity induced by methamphetamine (MAP) and nicotine (NIC), which enhances DA release and induces TH enzyme activation, respectively. Surprisingly, however, the intensity of MAP (2.5 mg/kg, once a day for 14 days)-induced hyperlocomotion in the nTg mice was greater than that in the Tg mice, and, furthermore, the Tg mice were less sensitive to subacute administration of NIC (0.5 mg/kg, once a day for 14 days) than the nTg mice. These results suggest that DAergic neuronal function is suppressed in Tg mice to compensate for the overexpression of TH.

元の言語English
ページ(範囲)41-49
ページ数9
ジャーナルJournal of Neural Transmission
97
発行部数1
DOI
出版物ステータスPublished - 01-02-1994
外部発表Yes

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Methamphetamine
Tyrosine 3-Monooxygenase
Locomotion
Nicotine
Transgenic Mice
Genes
Enzyme Activation

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

これを引用

Nabeshima, Toshitaka ; Itoh, A. ; Kobayashi, K. ; Morita, S. ; Mizuguchi, T. ; Sawada, H. ; Nitta, A. ; Hasegawa, T. ; Hayashi, K. ; Nagatsu, T. / Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene. :: Journal of Neural Transmission. 1994 ; 巻 97, 番号 1. pp. 41-49.
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abstract = "We produced transgenic (Tg) mice carrying the human tyrosine hydroxylase (TH) gene. To investigate differences in the dopaminergic (DAergic) neuronal activity between the Tg and nTg mice, we examined changes in the locomotor activity induced by methamphetamine (MAP) and nicotine (NIC), which enhances DA release and induces TH enzyme activation, respectively. Surprisingly, however, the intensity of MAP (2.5 mg/kg, once a day for 14 days)-induced hyperlocomotion in the nTg mice was greater than that in the Tg mice, and, furthermore, the Tg mice were less sensitive to subacute administration of NIC (0.5 mg/kg, once a day for 14 days) than the nTg mice. These results suggest that DAergic neuronal function is suppressed in Tg mice to compensate for the overexpression of TH.",
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Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene. / Nabeshima, Toshitaka; Itoh, A.; Kobayashi, K.; Morita, S.; Mizuguchi, T.; Sawada, H.; Nitta, A.; Hasegawa, T.; Hayashi, K.; Nagatsu, T.

:: Journal of Neural Transmission, 巻 97, 番号 1, 01.02.1994, p. 41-49.

研究成果: Article

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T1 - Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene

AU - Nabeshima, Toshitaka

AU - Itoh, A.

AU - Kobayashi, K.

AU - Morita, S.

AU - Mizuguchi, T.

AU - Sawada, H.

AU - Nitta, A.

AU - Hasegawa, T.

AU - Hayashi, K.

AU - Nagatsu, T.

PY - 1994/2/1

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