Effects of successive carbon monoxide exposures on delayed neuronal death in mice under the maintenance of normal body temperature

Hirohisa Ishimaru, Toshitaka Nabeshima, Akira Katoh, Hirotaka Suzuki, Taneo Fukuta, Tsutomu Kameyama

研究成果: Article

31 引用 (Scopus)

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The 3 time carbon monoxide (CO) exposures potentiated the delayed neuronal death (DND) in comparison with that induced by single CO exposure. Deterioration of DND induced by CO exposures was observed when normal body temperature was maintained during the exposures, since CO exposure fell the body temperature to about 34°C. Pretreatment with noncompetitive NMDA receptor antagonist, MK-801 (30 nmol/mouse), ameliorated DND induced by successive CO exposures under the maintenance of normal body temperature. These results suggest that the mice exposed successively to CO under the maintenance of normal body temperature is a useful hypoxic model.

元の言語English
ページ(範囲)836-840
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
179
発行部数2
DOI
出版物ステータスPublished - 16-09-1991
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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