Effects of the subacute administration of nefiracetam on abnormal behavior in aged rats

Masaya Hasegawa, Shinobu Nakayama, Hiroshi Kinoshita, Manabu Amano, Kiyofumi Yamada, Takaaki Hasegawa, Toshitaka Nabeshima

研究成果: Article

11 引用 (Scopus)

抜粋

We investigated the effects of nefiracetam on learning and memory by the Morris water maze task and water-finding test, and on emotional behavior by forced swimming, hole-board and open-held tests in old male Kbl Wistar rats aged 90 and 108 weeks. In the water maze task, the acquisition of the task in aged rats was slower than that in young rats. Subacute administration of nefiracetam (1 and 3 mg/kg daily) for 24 days tended to shorten the goal latency to escape onto the platform in a dose-dependent manner in the retention test, conducted 24 days after acquisition training. Nefiracetam (1 mg/kg) administration for 49 days decreased the duration of immobility in aged rats in the forced swimming test. Locomotor activity in young rats during the dark period was significantly higher than that during the light period, while there was no difference in locomotor activity between the light and dark periods in aged rats, suggesting that locomotor activity during the dark period and nocturnal habits. may be impaired in aged rats. Subacute administration of nefiracetam for 14 days significantly increased the locomotor activity during the dark, but not light, period in a dose-dependent manner. In addition, nefiracetam given for 38 days, significantly shortened the increased time elapsed before animals started exploring the environment in aged rats compared with young rats in the water-finding tests. These findings suggest that nefiracetam may improve the impaired nocturnal habits and some of emotional behavior in aged rats.

元の言語English
ページ(範囲)93-100
ページ数8
ジャーナルBehavioural Brain Research
78
発行部数2
DOI
出版物ステータスPublished - 08-1996
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

これを引用

Hasegawa, M., Nakayama, S., Kinoshita, H., Amano, M., Yamada, K., Hasegawa, T., & Nabeshima, T. (1996). Effects of the subacute administration of nefiracetam on abnormal behavior in aged rats. Behavioural Brain Research, 78(2), 93-100. https://doi.org/10.1016/0166-4328(95)00235-9