Effects of Various Amino Acids and Their Related Agents in Association with Neurotransmitter Substances on the Morphine-induced Straub Tail Reaction in Mice1

Tsutomu Kameyama, Makoto Ukai, Toshitaka Nabeshima

研究成果: Article

6 引用 (Scopus)

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Experiments were carried out in an attempt to elucidate the effects of various amino acids and their related agents in association with neurotransmitter substances on the morphine-induced Straub tail reaction (STR) in mice, using intracerebral injection technique. γ-Aminobutyric acid (GABA) and aminooxyacetic acid yielded significant decrement of the STR. Bicuculline provided the significant increment of the STR. DL-γ-Amino-β-hydroxybutyric acid and γ-guanidinobutyric acid had no influence on the STR. Glycine and taurine inhibited the STR significantly. L-Glutamic acid, L-aspartic acid, L-tyrosine and L-tryptophan had no influence on the STR. These results suggested the possibility that GABA, glycine and taurine may prevent the morphine-induced STR by means of an inhibitory action on the central nervous system in mice.

元の言語English
ページ(範囲)770-773
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
26
発行部数3
DOI
出版物ステータスPublished - 01-01-1978
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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