Efficacy of atorvastatin therapy in ischaemic heart disease - Effects on oxidized low-density lipoprotein and adiponectin

K. Miyagishima, Shinya Hiramitsu, S. Kato, Y. Kato, F. Kitagawa, R. Teradaira, R. Shinohara, K. Mori, H. Kimura, T. Ueda, M. Ohtsuki, S. Morimoto, H. Hishida

研究成果: Article

22 被引用数 (Scopus)

抄録

The lipid-lowering and anti-atherosclerotic effects of atorvastatin (10 mg/day) were investigated by measuring changes in the levels of oxidized low-density lipoprotein (LDL), serum lipids (total cholesterol [TC], LDL-cholesterol [LDL-C] and triglycerides [TG]), and in the protein adiponectin. This was undertaken in 22 patients with ischaemic heart disease and serum LDL-C levels > 100 mg/dl. After 3 months of therapy, atorvastatin significantly decreased serum lipids, oxidized LDL was reduced from 457.0 ± 148.6 to 286.9 ± 88.5 nmol/l, and adiponectin increased from 9.7 ± 7.4 to 13.9 ± 9.98 μg/ ml. No significant correlation was observed between adiponectin and LDL-C, TG and high-density lipoprotein cholesterol. Atorvastatin therapy was not associated with side-effects, such as myalgia and gastrointestinal disorders, and did not give abnormal laboratory test results. It is concluded that atorvastatin decreases serum lipid and oxidized LDL levels, and increases adiponectin levels in patients with ischaemic heart disease.

本文言語English
ページ(範囲)534-539
ページ数6
ジャーナルJournal of International Medical Research
35
4
DOI
出版ステータスPublished - 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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