Efficacy of chondroitin sulfate for painful knee osteoarthritis: A one-year, randomized, double-blind, multicenter clinical study in Japan

Mitsuhiro Morita, Kotaro Yamada, Hideki Date, Kazue Hayakawa, Hidetomo Sakurai, Harumoto Yamada

研究成果: Article査読

10 被引用数 (Scopus)

抄録

We explored the effects of chondroitin sulfate on knee osteoarthritis in a one-year, randomized, doubleblind, dose-comparison study. Patients with painful, Kellgren-Lawrence grade 2-3, osteoarthritis of the knee were treated with oral chondroitin sulfate at a dose of either 260 mg/d (low-dose group, control group) or 1560 mg/d (high-dose group). Symptoms were evaluated by the Lequesne's index and visual analog scale for pain. We made subgroup analyses according to background symptom severity (Lequesne's index ≥8 or <8) in 73 patients. Serum level of cartilage oligomeric matrix protein and hyaluronic acid were also determined. In the subgroup with severe symptoms (Lequesne's index ≥8), the chondroitin sulfate dose of 1560 mg/d improved pain faster after 6 and 9 months' therapy. However, no dose-related effects were found on cartilage oligomeric matrix protein or hyaluronic acid levels. Chondroitin sulfate also had good tolerability. We conclude that chondroitin sulfate is useful for pain control in knee osteoarthritis.

本文言語English
ページ(範囲)163-171
ページ数9
ジャーナルBiological and Pharmaceutical Bulletin
41
2
DOI
出版ステータスPublished - 2018

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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