Elevated aldosterone in amniotic fluid and maternal blood has diagnostic potential in pregnancies complicated with a fetus of bartter syndrome

Tamao Nakanishi, Nobuhiro Suzumori, Haruo Mizuno, Kazutaka Suzuki, Takeshi Sato, Mitsuyo Tanemura, Yoshikatsu Suzuki, Kaoru Suzumori

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Pregnancies with fetuses affected with the Bartter syndrome, an autosomal recessive disorder of hyperreninism and hyperaldosteronism, are complicated by early onset of polyhydramnios which results in preterm deliveries. We have assessed biochemical changes in amniotic fluid and the mother's blood with a view to early diagnosis. Aldosterone levels of both amniotic fluid and the mother's blood were found to be increased at 27 weeks of gestation, while electrolyte levels did not differ significantly from those reported earlier for controls. After birth the baby suffered from polyuria with hyponatremia, hypomagnesemia and hypercalciuria which could be controlled by treatment with sodium chloride and magnesium. Elevated aldosterone thus might be a useful marker for early diagnostic purposes.

本文言語English
ページ(範囲)481-484
ページ数4
ジャーナルFetal Diagnosis and Therapy
20
6
DOI
出版ステータスPublished - 11-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 胎生学
  • 放射線学、核医学およびイメージング
  • 産婦人科学

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