Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers

Toshifumi Hara, Yuuki Tominaga, Koji Ueda, Keichiro Mihara, Kazuyoshi Yanagihara, Yoshifumi Takei

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Methylation, the most common chemical modification of cellular components such as DNA, RNA, and proteins, impacts biological processes including transcription, RNA processing, and protein dynamics. Although abnormal expression of methyltransferase can lead to various diseases including cancers, little is known about the relationship between methyltransferase and cancers. Here we aimed to understand the role of methyltransferase in cancer metastasis. We found that elevated methyltransferase-like 9 (METTL9) is closely associated with the acquisition of metastatic activity in human scirrhous gastric cancers. The stable knockdown of METTL9 via an shRNA vector technique in our original metastatic cells from scirrhous gastric cancer patients significantly inhibited migration and invasion. In metastatic cells, METTL9 protein is predominantly localized in mitochondria, and the METTL9 knockdown significantly reduced mitochondrial Complex I activity. METTL9 can be a candidate of molecular targets to inhibit peritoneal dissemination of scirrhous gastric cancers. This report is the first to describe the relationship between METTL9 and cancer metastasis.

本文言語English
論文番号101255
ジャーナルBiochemistry and Biophysics Reports
30
DOI
出版ステータスPublished - 07-2022

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学

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