Elevated steroid sulfatase expression in breast cancers

Toshiaki Utsumi, Noriko Yoshimura, Shinji Takeuchi, Morito Maruta, Kotaro Maeda, Nobuhiro Harada

研究成果: Article査読

92 被引用数 (Scopus)

抄録

In situ estrogen synthesis makes an important contribution to the high estrogen concentration found in breast cancer tissues. Steroid sulfatase which hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate may be involved. In the present study, we therefore, assessed steroid sulfatase mRNA levels in breast malignancies and background tissues from 38 patients by reverse transcription and polymerase chain reaction. The levels in breast cancer tissues were significantly increased at 1458.4±2119.7 attomoles/mg RNA (mean ± SD) as compared with 535.6±663.4 attomoles/mg RNA for non-malignant tissues (P<0.001). Thus, increased steroid sulfatase expression may be partly responsible for local overproduction of estrogen and provide a growth advantage for tumor cells. Copyright (C) 2000 Elsevier Science Ltd.

本文言語English
ページ(範囲)141-145
ページ数5
ジャーナルJournal of Steroid Biochemistry and Molecular Biology
73
3-4
DOI
出版ステータスPublished - 01-06-2000

All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 分子医療
  • 分子生物学
  • 内分泌学
  • 臨床生化学
  • 細胞生物学

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