TY - JOUR
T1 - Elevation of superoxide dismutase increases acoustic trauma from noise exposure
AU - Endo, Tsuyoshi
AU - Nakagawa, Takayuki
AU - Iguchi, Fukuichiro
AU - Kita, Tomoko
AU - Okano, Takayuki
AU - Sha, Su Hua
AU - Schacht, Jochen
AU - Shiga, Atsushi
AU - Kim, Tae Soo
AU - Ito, Juichi
PY - 2005/2/15
Y1 - 2005/2/15
N2 - The generation of superoxide has been implicated as a cause of cochlear damage from excessive noise. Cu/Zn superoxide dismutase (SOD1) generally will protect against superoxide-mediated tissue injury but protection by this enzyme against noise trauma is controversial. This study assessed auditory function in C57BL/6 mice overexpressing SOD1 or treated with lecithinized SOD1 (PC-SOD1). Noise exposure caused significantly higher threshold shifts in PC-SOD1-treated animals than physiological saline-treated animals. Cochlear tissues of PC-SOD1-treated animals exhibited significant elevation of the levels in the SOD activity, not in the catalase activity, in comparison with those of saline-treated animals. Likewise, transgenic mice overexpressing SOD1 tended to suffer higher threshold shifts than nontransgenic littermates from noise exposure. The findings indicate that increasing SOD1 enhances auditory dysfunction following noise exposure.
AB - The generation of superoxide has been implicated as a cause of cochlear damage from excessive noise. Cu/Zn superoxide dismutase (SOD1) generally will protect against superoxide-mediated tissue injury but protection by this enzyme against noise trauma is controversial. This study assessed auditory function in C57BL/6 mice overexpressing SOD1 or treated with lecithinized SOD1 (PC-SOD1). Noise exposure caused significantly higher threshold shifts in PC-SOD1-treated animals than physiological saline-treated animals. Cochlear tissues of PC-SOD1-treated animals exhibited significant elevation of the levels in the SOD activity, not in the catalase activity, in comparison with those of saline-treated animals. Likewise, transgenic mice overexpressing SOD1 tended to suffer higher threshold shifts than nontransgenic littermates from noise exposure. The findings indicate that increasing SOD1 enhances auditory dysfunction following noise exposure.
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U2 - 10.1016/j.freeradbiomed.2004.11.008
DO - 10.1016/j.freeradbiomed.2004.11.008
M3 - Article
C2 - 15649651
AN - SCOPUS:13844299247
SN - 0891-5849
VL - 38
SP - 492
EP - 498
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
IS - 4
ER -