Endarteritis obliterans in the pathogenesis of buerger’s disease from the pathological and immunohistochemical points of view

Masayoshi Kobayashi, Masayuki Sugimoto, Kimihiro Komori

研究成果: Review article査読

14 被引用数 (Scopus)

抄録

Buerger’s disease (thromboangiitis obliterans) is considered to be a nonatherosclerotic, inflammatory, and vasoocclusive disease, although the details of the mechanisms of pathogenesis remain unknown. The occurrence of the disease is strongly related to tobacco abuse and its progression is closely linked to continued smoking. The purpose of this review article is to demonstrate the pathological characteristics of arteries affected with Buerger’s disease from a possible immunoreactive point of view. In addition, we present the mechanisms for preserving the architecture of the arterial wall in affected vasculatures. Thereafter, we discuss the possibility that the pathogenesis of Buerger’s disease is a type of endarteritis obliterans, deeply connected to the Notch pathway, distinct from arteriosclerosis obliterans and other vasculitides.

本文言語English
ページ(範囲)2819-2826
ページ数8
ジャーナルCirculation Journal
78
12
DOI
出版ステータスPublished - 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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