Endogenous human herpesviruses 6A/B

Louis Flamand; Jesse Arbuckle; Pascale Bonnafous; Vincent Descamps; Joshua A. Hill; Ruth Jarrett; Keith Jerome; Benedikt B. Kaufer; Rie Koide; Anthony L. Komaroff; Peter Medveczky; Hiroki Miura; Yasuko Mori; Nicholas Parrish; Philip E. Pellett; Michael Wood; Tetsushi Yoshikawa; Danielle M. Zerr

doi:10.1128/jvi.01054-25

Endogenous human herpesviruses 6A/B

Louis Flamand
, Jesse Arbuckle
, Pascale Bonnafous
, Vincent Descamps
, Joshua A. Hill
, Ruth Jarrett
, Keith Jerome
, Benedikt B. Kaufer
, Rie Koide
, Anthony L. Komaroff
, Peter Medveczky
, Hiroki Miura
, Yasuko Mori
, Nicholas Parrish
, Philip E. Pellett
, Michael Wood
, Tetsushi Yoshikawa
, Danielle M. Zerr

小児科学

研究成果: ジャーナルへの寄稿 › 総説 › 査読

3 被引用数 (Scopus)

抄録

Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA—now proposed to be called “endogenous HHV-6A/B (eHHV-6A/B).” Present in 0.2–3% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using “eHHV-6A/B” for inherited forms and reserving “chromosomally integrated” for somatic integrations only.

本文言語	英語
ジャーナル	Journal of Virology
巻	99
号	9
DOI	https://doi.org/10.1128/jvi.01054-25
出版ステータス	出版済み - 09-2025

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All Science Journal Classification (ASJC) codes

微生物学
免疫学
昆虫科学
ウイルス学

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10.1128/jvi.01054-25

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@article{6112827cfad54436998a64ac3c11bac7,

title = "Endogenous human herpesviruses 6A/B",

abstract = "Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA{\textemdash}now proposed to be called {\textquotedblleft}endogenous HHV-6A/B (eHHV-6A/B).{\textquotedblright} Present in 0.2{\textendash}3\% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using {\textquotedblleft}eHHV-6A/B{\textquotedblright} for inherited forms and reserving {\textquotedblleft}chromosomally integrated{\textquotedblright} for somatic integrations only.",

keywords = "HHV-6, eHHV-6, endogenous HHV-6, human herpesvirus 6, iciHHV-6, inherited chromosomally integrated HHV-6",

author = "Louis Flamand and Jesse Arbuckle and Pascale Bonnafous and Vincent Descamps and Hill, \{Joshua A.\} and Ruth Jarrett and Keith Jerome and Kaufer, \{Benedikt B.\} and Rie Koide and Komaroff, \{Anthony L.\} and Peter Medveczky and Hiroki Miura and Yasuko Mori and Nicholas Parrish and Pellett, \{Philip E.\} and Michael Wood and Tetsushi Yoshikawa and Zerr, \{Danielle M.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 Flamand et al.",

year = "2025",

month = sep,

doi = "10.1128/jvi.01054-25",

language = "English",

volume = "99",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Endogenous human herpesviruses 6A/B

AU - Flamand, Louis

AU - Arbuckle, Jesse

AU - Bonnafous, Pascale

AU - Descamps, Vincent

AU - Hill, Joshua A.

AU - Jarrett, Ruth

AU - Jerome, Keith

AU - Kaufer, Benedikt B.

AU - Koide, Rie

AU - Komaroff, Anthony L.

AU - Medveczky, Peter

AU - Miura, Hiroki

AU - Mori, Yasuko

AU - Parrish, Nicholas

AU - Pellett, Philip E.

AU - Wood, Michael

AU - Yoshikawa, Tetsushi

AU - Zerr, Danielle M.

PY - 2025/9

Y1 - 2025/9

N2 - Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA—now proposed to be called “endogenous HHV-6A/B (eHHV-6A/B).” Present in 0.2–3% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using “eHHV-6A/B” for inherited forms and reserving “chromosomally integrated” for somatic integrations only.

AB - Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA—now proposed to be called “endogenous HHV-6A/B (eHHV-6A/B).” Present in 0.2–3% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using “eHHV-6A/B” for inherited forms and reserving “chromosomally integrated” for somatic integrations only.

KW - HHV-6

KW - eHHV-6

KW - endogenous HHV-6

KW - human herpesvirus 6

KW - iciHHV-6

KW - inherited chromosomally integrated HHV-6

UR - https://www.scopus.com/pages/publications/105016792236

UR - https://www.scopus.com/pages/publications/105016792236#tab=citedBy

U2 - 10.1128/jvi.01054-25

DO - 10.1128/jvi.01054-25

M3 - Review article

C2 - 40748144

AN - SCOPUS:105016792236

SN - 0022-538X

VL - 99

JO - Journal of Virology

JF - Journal of Virology

IS - 9

ER -

Endogenous human herpesviruses 6A/B

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All Science Journal Classification (ASJC) codes

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