Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens

Berthony Deslouches; Jonathan D. Steckbeck; Jodi K. Craigo; Yohei Doi; Jane L. Burns; Ronald C. Montelaro

doi:10.1128/AAC.03937-14

Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens

Berthony Deslouches
, Jonathan D. Steckbeck
, Jodi K. Craigo
, Yohei Doi
, Jane L. Burns
, Ronald C. Montelaro

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

115 被引用数 (Scopus)

抄録

Multidrug resistance constitutes a threat to the medical achievements of the last 50 years. In this study, we demonstrated the abilities of two de novo engineered cationic antibiotic peptides (eCAPs), WLBU2 and WR12, to overcome resistance from 142 clinical isolates representing the most common multidrug-resistant (MDR) pathogens and to display a lower propensity to select for resistant bacteria in vitro compared to that with colistin and LL37. The results warrant an exploration of eCAPs for use in clinical settings.

本文言語	英語
ページ（範囲）	1329-1333
ページ数	5
ジャーナル	Antimicrobial agents and chemotherapy
巻	59
号	2
DOI	https://doi.org/10.1128/AAC.03937-14
出版ステータス	出版済み - 01-02-2015
外部発表	はい

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All Science Journal Classification (ASJC) codes

薬理学
薬理学（医学）
感染症

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AU - Steckbeck, Jonathan D.

AU - Craigo, Jodi K.

AU - Doi, Yohei

AU - Burns, Jane L.

AU - Montelaro, Ronald C.

PY - 2015/2/1

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AB - Multidrug resistance constitutes a threat to the medical achievements of the last 50 years. In this study, we demonstrated the abilities of two de novo engineered cationic antibiotic peptides (eCAPs), WLBU2 and WR12, to overcome resistance from 142 clinical isolates representing the most common multidrug-resistant (MDR) pathogens and to display a lower propensity to select for resistant bacteria in vitro compared to that with colistin and LL37. The results warrant an exploration of eCAPs for use in clinical settings.

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Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens

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UN SDG

All Science Journal Classification (ASJC) codes

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