Enhanced effect of clarithromycin on neutrophil function in vitro

H. Akamatsu; Y. Niwa; H. Sasaki; Y. Asada; T. Horio

doi:10.1177/030006059602400202

Enhanced effect of clarithromycin on neutrophil function in vitro

H. Akamatsu
, Y. Niwa
, H. Sasaki
, Y. Asada
, T. Horio

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

抄録

An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O₂^-, H₂O₂ and OH. levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.

本文言語	英語
ページ（範囲）	185-189
ページ数	5
ジャーナル	Journal of International Medical Research
巻	24
号	2
DOI	https://doi.org/10.1177/030006059602400202
出版ステータス	出版済み - 1996
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
細胞生物学
生化学、医学

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10.1177/030006059602400202

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abstract = "An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O2-, H2O2 and OH. levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.",

author = "H. Akamatsu and Y. Niwa and H. Sasaki and Y. Asada and T. Horio",

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AU - Akamatsu, H.

AU - Niwa, Y.

AU - Sasaki, H.

AU - Asada, Y.

AU - Horio, T.

PY - 1996

Y1 - 1996

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AB - An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O2-, H2O2 and OH. levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.

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Enhanced effect of clarithromycin on neutrophil function in vitro

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