Enhanced production of leukotriene B4 by peripheral blood mononuclear cells in patients with fulminant hepatitis

F. ASANO, H. MORIWAKI, Y. SHIRATORI, M. SHIMAZAKI, T. SAKAI, Y. KOSHINO, N. MURAKAMI, J. SUGIHARA, H. OHNISHI, K. SAITO, Y. MUTO

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Abstract The production rate of leukotriene B4 (LTB4) was measured using peripheral blood mononuclear cells (PBMC) in patients with fulminant hepatitis (FH) or other liver diseases. LTB4 in the culture media of PBMC under stimulation with Ca‐ionophore was fractionated by HPLC and measured by radioimmunoassay. The production rate of LTB4 was elevated in 16 of 17 FH patients (3.3 ± 0.2 ng/106 cells for 5 min), while the production was below detectable level in patients with acute or chronic hepatitis and in healthy controls. In FH patients, the highest production rate of LTB4 was observed in the initial period of the disease. Enhanced LTB4 production may indicate the primed state of PBMC — the primed mononuclear cells are regarded as participating in the development of massive liver necrosis and of other organ failures in FH.

本文言語English
ページ(範囲)228-231
ページ数4
ジャーナルJournal of Gastroenterology and Hepatology
8
3
DOI
出版ステータスPublished - 06-1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

フィンガープリント 「Enhanced production of leukotriene B<sub>4</sub> by peripheral blood mononuclear cells in patients with fulminant hepatitis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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