Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule

Kazuhiro Nakamura, Toshiya Manabe, Masahiko Watanabe, Takayoshi Mamiya, Ryoichi Ichikawa, Yuji Kiyama, Makoto Sanbo, Takeshi Yagi, Yoshiro Inoue, Toshitaka Nabeshima, Hisashi Mori, Masayoshi Mishina

研究成果: Article

66 引用 (Scopus)

抜粋

Telencephalin (TLCN) is a cell adhesion molecule selectively expressed in the telencephalon of the mammalian brain. The mutant mice lacking TLCN had no detectable abnormalities in their neural development and synaptic structures. Ablation of TLCN increased the hippocampal long-term potentiation and its saturation level. The TLCN mutation selectively enhanced the performance of the radial maze and water-finding tasks, learning tasks with appetitive reinforcers, but not the contextual fear conditioning and Morris water maze tasks with aversive stimuli for conditioning. Furthermore, the TLCN mutant mice showed an increase of prepulse inhibition of the acoustic startle response. These results suggest that TLCN is a determinant of the dynamic range of synaptic plasticity and plays roles in reward-motivated learning and memory and sensorimotor gating.

元の言語English
ページ(範囲)179-189
ページ数11
ジャーナルEuropean Journal of Neuroscience
13
発行部数1
DOI
出版物ステータスPublished - 30-01-2001
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Nakamura, K., Manabe, T., Watanabe, M., Mamiya, T., Ichikawa, R., Kiyama, Y., Sanbo, M., Yagi, T., Inoue, Y., Nabeshima, T., Mori, H., & Mishina, M. (2001). Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. European Journal of Neuroscience, 13(1), 179-189. https://doi.org/10.1046/j.0953-816X.2000.01366.x