Enhancement of immobility induced by repeated phencyclidine injection: Association with c-Fos protein in the mouse brain

Merfat Abdel-Naby Sayed, Yukihiro Noda, Moustafa Mahmoud Hamdy, Takayoshi Mamiya, Taku Nagai, Hiroshi Furukawa, Toshitaka Nabeshima

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Immunohistochemistry of c-Fos protein was performed to study changes in neuronal activity in discrete brain areas of mice repeatedly treated with phencyclidine (PCP) showing enhancement of immobility in the forced swimming test, this behavioral change being considered as avolition, which is one of negative symptoms of schizophrenia. Repeated treatment with PCP significantly prolonged immobility time in the forced swimming test, compared with saline treatment. The c-Fos protein expression of mice showing PCP-induced enhancement of immobility was increased in certain brain regions, such as the retrosplenial cortex, pyriform cortices, pontine nuclei, cingulate, frontal cortex and thalamus, compared with that of PCP-treated, non-swimming and saline-treated, swimming groups. These results suggest that increased c-Fos protein is involved in the expression of PCP-induced enhancement of immobility, and c-Fos expression plays a role in negative symptoms-like behavioral changes.

本文言語English
ページ(範囲)71-76
ページ数6
ジャーナルBehavioural Brain Research
124
1
DOI
出版ステータスPublished - 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 行動神経科学

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